Hypercalciuria may persist after successful parathyroid surgery and it is associated with parathyroid hyperplasia

Serena Palmieri, Cristina Eller-Vainicher, Elisa Cairoli, Valentina Morelli, Volha V. Zhukouskaya, Uberta Verga, Marcello Filopanti, Leonardo Vicentini, Stefano Ferrero, Anna Spada, Iacopo Chiodini

Research output: Contribution to journalArticle

Abstract

Context: Hypercalciuria is frequently found in primary hyperparathyroidism (1HPT) and, although it generally normalizes after successful parathyroidectomy, may persist in some patients. The factors associated with persistent calcium renal leak (cRL) have not been clarified. Objective: The purpose of this study was to determine the prevalence of cRL in our 1HPT population and investigate cRL-related factors. Design: This was a retrospective longitudinal study. Setting: The study was conducted in an outpatient setting. Patients/Intervention: The participants were 95 patients with 1HPT successfully operated on who had a normal estimated glomerular filtration rate. Main Outcome Measures: The biochemical parameters of calcium metabolism and bone mineral density (BMD) measured by dual-X-ray absorptiometry before and 24 months after surgery were assessed. All histological findings were recorded. Results: Theprevalence of hypercalciuria beforeandafter surgerywas74%and32%,respectively. Before, surgerypatientswithcRLshowedlowercalciumandhigherphosphatelevelsthanthosewithoutcRL(10.9± 0.6 vs 11.4±0.8 mg/dL [2.7±0.2 vs 2.8±0.2 mmol/L], P

Original languageEnglish
Pages (from-to)2734-2742
Number of pages9
JournalJournal of Clinical Endocrinology and Metabolism
Volume100
Issue number7
DOIs
Publication statusPublished - Jul 1 2015

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

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