Hypercholesterolaemia is not associated with early atherosclerotic lesions in primary biliary cirrhosis

M. Allocca, A. Crosignani, A. Gritti, G. Ghilardi, D. Gobatti, D. Caruso, M. Zuin, M. Podda, P. M. Battezzati

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Hypercholesterolaemia often occurs in primary biliary cirrhosis (PBC) as a result of chronic cholestasis, but whether these patients are exposed to greater cardiovascular risk is unknown. Aim: To establish whether hypercholesterolaemia is associated with subclinical atherosclerosis in PBC. Patients: 103 consecutive patients with PBC (37 with total cholesterol ≥6.21 mmol/l) and 37 controls with hypercholesterolaemia, and 141 matched controls with normocholesterolaemia. Methods: Ultrasound imaging of carotid artery to determine intima-media thickness (IMT) and stenosis. Results: Controls with hypercholesterolaemia had higher IMT and prevalence of carotid stenosis compared with patients with hypercholesterolaemic PBC (mean (SD) 0.850 (0.292) mm v 0.616 (0.137) mm, pcc = 0.129) who, in turn, were similar to the 66 patients with normocholesterolaemic PBC (0.600 (0.136) mm; 5%). Compared with subjects with normocholesterolaemia, controls with hypercholesterolaemia, but not patients with hypercholesterolaemic PBC, had an increased risk of raised IMT (odds ratio (OR) 5.4, 95% confidence interval (CI) 2.5 to 11.9, p

Original languageEnglish
Pages (from-to)1795-1800
Number of pages6
JournalGut
Volume55
Issue number12
DOIs
Publication statusPublished - Dec 2006

ASJC Scopus subject areas

  • Gastroenterology

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