Hypercoagulability and the risk of recurrence in young women with myocardial infarction or ischaemic stroke: A cohort study 11 Medical and Health Sciences 1102 Cardiorespiratory Medicine and Haematology

Alberto Maino, Ale Algra, Flora Peyvandi, Frits Richard Rosendaal, Bob Siegerink

Research output: Contribution to journalArticle

Abstract

Background: We aimed to investigate the role of hypercoagulability on the risk of lifetime cardiovascular recurrences after myocardial infarction or ischaemic stroke. Methods: Young women (< 50 years) with either myocardial infarction (n = 197) or ischaemic stroke (n = 107) were followed between 1995 and 2012 in the RATIO follow-up study. To determine whether hypercoagulability affects the risk or recurrence, a coagulation score based on acquired and inherited markers was compiled and used in a quartile analysis. Hazard ratios (HRs) obtained from Cox proportional models and adjusted for several cardiovascular risk factors were used to compare quartiles of the coagulation score for the risk of recurrence. Results: During a median follow-up of 19 years, 59 cardiovascular recurrences occurred. In patients with myocardial infarction no association was found between a high prothrombotic score and recurrences (highest quartile vs lowest quartile HR 0.7, 95% CI, 0.3-1.8). Conversely, ischaemic stroke patients with a high prothrombotic score showed a doubling in risk of long-term cardiovascular recurrences (HR 1.9, 95% CI 0.6-6.3) compared with ischaemic stroke patients and low levels of the score, with a dose response relationship. Conclusions: An increased coagulation tendency might be associated with long-term cardiovascular risk in women with ischaemic stroke, but not in women with myocardial infarction.

Original languageEnglish
Article number55
JournalBMC Cardiovascular Disorders
Volume19
Issue number1
DOIs
Publication statusPublished - Mar 7 2019

Keywords

  • Myocardial infarction
  • Prognosis
  • Recurrences
  • Stroke in young adults
  • Thrombosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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