TY - JOUR
T1 - Hypercoagulability and Vascular Disease
AU - Taher, Ali T.
AU - Cappellini, Maria Domenica
AU - Bou-Fakhredin, Rayan
AU - Coriu, Daniel
AU - Musallam, Khaled M.
PY - 2018/4/1
Y1 - 2018/4/1
N2 - The presence of a high incidence of thrombotic events, mainly in nontransfusion-dependent β-thalassemia syndromes, has led to the identification of a hypercoagulable state in thalassemia patients. This article highlights the mechanisms leading to hypercoagulability in thalassemia. It also discusses the clinical experience and available evidence on prevention and management approaches.
AB - The presence of a high incidence of thrombotic events, mainly in nontransfusion-dependent β-thalassemia syndromes, has led to the identification of a hypercoagulable state in thalassemia patients. This article highlights the mechanisms leading to hypercoagulability in thalassemia. It also discusses the clinical experience and available evidence on prevention and management approaches.
KW - Cerebrovascular disease
KW - Hypercoagulable state
KW - Pulmonary hypertension
KW - Thrombosis
UR - http://www.scopus.com/inward/record.url?scp=85035226573&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85035226573&partnerID=8YFLogxK
U2 - 10.1016/j.hoc.2017.11.001
DO - 10.1016/j.hoc.2017.11.001
M3 - Review article
AN - SCOPUS:85035226573
VL - 32
SP - 237
EP - 245
JO - Hematology/Oncology Clinics of North America
JF - Hematology/Oncology Clinics of North America
SN - 0889-8588
IS - 2
ER -