Hypercoagulability, high tissue factor and low tissue factor pathway inhibitor levels in severe ovarian hyperstimulation syndrome: Possible association with clinical outcome

Angela Rogolino, Maria Elisabetta Coccia, Sandra Fedi, Anna Maria Gori, Anna Paola Cellai, Gian Franco Scarselli, Domenico Prisco, Rosanna Abbate

Research output: Contribution to journalArticle

Abstract

During ovarian gonadotrophin stimulation for ovulation induction or in vitro fertilization, a clinical severe ovarian hyperstimulation syndrome (OHSS) may occur. Only few studies have investigated the mechanism responsible for the alterations of the haemostatic system in women affected by severe OHSS. The aim of the present study was to investigate the correlation between the magnitude of ovarian stimulation and the increase in fibrin formation and degradation in severe OHSS. Twenty-five patients (age range 23-43 years) who were hospitalized for severe OHSS, 25 women undergoing in vitro fertilization who did not develop OHSS (case-control group) and 25 healthy age-matched women (healthy control group) were investigated. On the day of admission a number of haemostatic markers, including D-dimer, thrombin-antithrombin complexes (TAT), prothrombin fragment 1 + 2 (F1 + 2), plasmin-antiplasmin complexes (PAP), tissue factor (TF), tissue factor pathway inhibitor (TFPI) and von Willebrand factor antigen (vWF), were examined. In patients with severe OHSS, TF, D-dimer, TAT, F1 + 2, PAP and vWF antigen plasma levels were significantly higher than those observed both in the case-control group and in healthy controls, whereas TFPI levels were significantly lower (P

Original languageEnglish
Pages (from-to)277-282
Number of pages6
JournalBlood Coagulation and Fibrinolysis
Volume14
Issue number3
DOIs
Publication statusPublished - Apr 2003

Keywords

  • Coagulation
  • Fibrinolysis
  • Severe ovarian hyperstimulation syndrome
  • Tissue factor
  • Tissue factor pathway inhibitor

ASJC Scopus subject areas

  • Hematology

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