Abstract
Life expectancy of thalassemia patients has markedly improved over the last few decades, but patients still suffer from many complications of their congenital chronic disease, and several new complications are now being acknowledged, including thrombosis. The high prevalence of thromboembolic events, especially in thalassemia intermedia, has led to the identification of a hypercoagulable state in these patients. This review summarizes current knowledge of the clinical and pathophysiological characteristics of hypercoagulability in thalassemia patients. Strategies to prevent thrombotic events are also discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 505-512 |
| Number of pages | 8 |
| Journal | Expert Review of Hematology |
| Volume | 5 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Oct 2012 |
Fingerprint
Keywords
- coagulopathy
- hypercoagulability
- thalassemia intermedia
- thalassemia major
- thrombosis
ASJC Scopus subject areas
- Hematology
Cite this
Hypercoagulability in β-thalassemia : A status quo. / Cappellini, Maria Domenica; Poggiali, Erika; Taher, Ali T.; Musallam, Khaled M.
In: Expert Review of Hematology, Vol. 5, No. 5, 10.2012, p. 505-512.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hypercoagulability in β-thalassemia
T2 - A status quo
AU - Cappellini, Maria Domenica
AU - Poggiali, Erika
AU - Taher, Ali T.
AU - Musallam, Khaled M.
PY - 2012/10
Y1 - 2012/10
N2 - Life expectancy of thalassemia patients has markedly improved over the last few decades, but patients still suffer from many complications of their congenital chronic disease, and several new complications are now being acknowledged, including thrombosis. The high prevalence of thromboembolic events, especially in thalassemia intermedia, has led to the identification of a hypercoagulable state in these patients. This review summarizes current knowledge of the clinical and pathophysiological characteristics of hypercoagulability in thalassemia patients. Strategies to prevent thrombotic events are also discussed.
AB - Life expectancy of thalassemia patients has markedly improved over the last few decades, but patients still suffer from many complications of their congenital chronic disease, and several new complications are now being acknowledged, including thrombosis. The high prevalence of thromboembolic events, especially in thalassemia intermedia, has led to the identification of a hypercoagulable state in these patients. This review summarizes current knowledge of the clinical and pathophysiological characteristics of hypercoagulability in thalassemia patients. Strategies to prevent thrombotic events are also discussed.
KW - coagulopathy
KW - hypercoagulability
KW - thalassemia intermedia
KW - thalassemia major
KW - thrombosis
UR - http://www.scopus.com/inward/record.url?scp=84869151495&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84869151495&partnerID=8YFLogxK
U2 - 10.1586/ehm.12.42
DO - 10.1586/ehm.12.42
M3 - Article
VL - 5
SP - 505
EP - 512
JO - Expert Review of Hematology
JF - Expert Review of Hematology
SN - 1747-4086
IS - 5
ER -