Hypercoagulability is a stronger risk factor for ischaemic stroke than for myocardial infarction: A systematic review

Alberto Maino; Frits R. Rosendaal; Ale Algra; Flora Peyvandi; Bob Siegerink

doi:10.1371/journal.pone.0133523

Hypercoagulability is a stronger risk factor for ischaemic stroke than for myocardial infarction: A systematic review

Alberto Maino, Frits R. Rosendaal, Ale Algra, Flora Peyvandi, Bob Siegerink

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

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Abstract

Background and Purpose: Hypercoagulability increases the risk of arterial thrombosis; however, this effect may differ between various manifestations of arterial disease. Methods: In this study, we compared the effect of coagulation factors asmeasures of hypercoagulability on the risk of ischaemic stroke (IS) and myocardial infarction (MI) by performing a systematic review of the literature. The effect of a risk factor on IS (relative risk for IS, RR_IS) was compared with the effect on MI (RR_MI) by calculating their ratio (RRR = RR_IS/RR_MI). A relevant differential effect was considered when RRR was >1+ its own standard error (SE) or 1+1SE) was found in 49/343 (14%) markers. Of these, 18/49 (37%) had an RRR greater than 1+2SE. On the opposite side, a larger effect on MI risk (RRR

Original language	English
Article number	e0133523
Journal	PLoS One
Volume	10
Issue number	8
DOIs	https://doi.org/10.1371/journal.pone.0133523
Publication status	Published - Aug 7 2015

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

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10.1371/journal.pone.0133523

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AU - Maino, Alberto

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AU - Peyvandi, Flora

AU - Siegerink, Bob

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Hypercoagulability is a stronger risk factor for ischaemic stroke than for myocardial infarction: A systematic review

Abstract

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