Hypercoagulability is a stronger risk factor for ischaemic stroke than for myocardial infarction: A systematic review

Alberto Maino, Frits R. Rosendaal, Ale Algra, Flora Peyvandi, Bob Siegerink

Research output: Contribution to journalArticlepeer-review

Abstract

Background and Purpose: Hypercoagulability increases the risk of arterial thrombosis; however, this effect may differ between various manifestations of arterial disease. Methods: In this study, we compared the effect of coagulation factors asmeasures of hypercoagulability on the risk of ischaemic stroke (IS) and myocardial infarction (MI) by performing a systematic review of the literature. The effect of a risk factor on IS (relative risk for IS, RRIS) was compared with the effect on MI (RRMI) by calculating their ratio (RRR = RRIS/RRMI). A relevant differential effect was considered when RRR was >1+ its own standard error (SE) or 1+1SE) was found in 49/343 (14%) markers. Of these, 18/49 (37%) had an RRR greater than 1+2SE. On the opposite side, a larger effect on MI risk (RRR

Original languageEnglish
Article numbere0133523
JournalPLoS One
Volume10
Issue number8
DOIs
Publication statusPublished - Aug 7 2015

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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