Abstract
Background and Purpose: Hypercoagulability increases the risk of arterial thrombosis; however, this effect may differ between various manifestations of arterial disease. Methods: In this study, we compared the effect of coagulation factors asmeasures of hypercoagulability on the risk of ischaemic stroke (IS) and myocardial infarction (MI) by performing a systematic review of the literature. The effect of a risk factor on IS (relative risk for IS, RRIS) was compared with the effect on MI (RRMI) by calculating their ratio (RRR = RRIS/RRMI). A relevant differential effect was considered when RRR was >1+ its own standard error (SE) or 1+1SE) was found in 49/343 (14%) markers. Of these, 18/49 (37%) had an RRR greater than 1+2SE. On the opposite side, a larger effect on MI risk (RRR
| Original language | English |
|---|---|
| Article number | e0133523 |
| Journal | PLoS One |
| Volume | 10 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 7 2015 |
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ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
Cite this
Hypercoagulability is a stronger risk factor for ischaemic stroke than for myocardial infarction : A systematic review. / Maino, Alberto; Rosendaal, Frits R.; Algra, Ale; Peyvandi, Flora; Siegerink, Bob.
In: PLoS One, Vol. 10, No. 8, e0133523, 07.08.2015.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hypercoagulability is a stronger risk factor for ischaemic stroke than for myocardial infarction
T2 - A systematic review
AU - Maino, Alberto
AU - Rosendaal, Frits R.
AU - Algra, Ale
AU - Peyvandi, Flora
AU - Siegerink, Bob
PY - 2015/8/7
Y1 - 2015/8/7
N2 - Background and Purpose: Hypercoagulability increases the risk of arterial thrombosis; however, this effect may differ between various manifestations of arterial disease. Methods: In this study, we compared the effect of coagulation factors asmeasures of hypercoagulability on the risk of ischaemic stroke (IS) and myocardial infarction (MI) by performing a systematic review of the literature. The effect of a risk factor on IS (relative risk for IS, RRIS) was compared with the effect on MI (RRMI) by calculating their ratio (RRR = RRIS/RRMI). A relevant differential effect was considered when RRR was >1+ its own standard error (SE) or 1+1SE) was found in 49/343 (14%) markers. Of these, 18/49 (37%) had an RRR greater than 1+2SE. On the opposite side, a larger effect on MI risk (RRR
AB - Background and Purpose: Hypercoagulability increases the risk of arterial thrombosis; however, this effect may differ between various manifestations of arterial disease. Methods: In this study, we compared the effect of coagulation factors asmeasures of hypercoagulability on the risk of ischaemic stroke (IS) and myocardial infarction (MI) by performing a systematic review of the literature. The effect of a risk factor on IS (relative risk for IS, RRIS) was compared with the effect on MI (RRMI) by calculating their ratio (RRR = RRIS/RRMI). A relevant differential effect was considered when RRR was >1+ its own standard error (SE) or 1+1SE) was found in 49/343 (14%) markers. Of these, 18/49 (37%) had an RRR greater than 1+2SE. On the opposite side, a larger effect on MI risk (RRR
UR - http://www.scopus.com/inward/record.url?scp=84941979158&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84941979158&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0133523
DO - 10.1371/journal.pone.0133523
M3 - Article
AN - SCOPUS:84941979158
VL - 10
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 8
M1 - e0133523
ER -