Hypercoagulable state induced by cytostatic drugs in Stage II breast cancer patients

L. Canobbio, T. Fassio, A. Ardizzoni, P. Bruzzi, M. A. Queirolo, D. Zarcone, F. Di Giorgio, R. Rosso, L. Santi

Research output: Contribution to journalArticlepeer-review


An increased incidence of thromboembolic complications occurring in cancer patients during chemotherapy was recently reported. In view of this report, a study in 49 patients receiving adjuvant chemotherapy for Stage II breast cancer was begun in order to determine the effect of antineoplastic drugs on coagulation factors and platelet function. Among the coagulation factors, a significant decrease of thrombin time and partial prothrombin time was observed, whereas platelet function tests were unchanged. This finding suggests a trend towards hypercoagulability induced by chemotherapy. This effect should be considered when chemotherapy is employed in advanced cancer patients at high risk for thrombosis.

Original languageEnglish
Pages (from-to)1032-1036
Number of pages5
Issue number5
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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