TY - JOUR
T1 - Hyperconnectivity in Dementia Is Early and Focal and Wanes with Progression
AU - FTD Italian study group-SINDEM
AU - Bonanni, Laura
AU - Moretti, Davide
AU - Benussi, Alberto
AU - Ferri, Laura
AU - Russo, Mirella
AU - Carrarini, Claudia
AU - Barbone, Filomena
AU - Arnaldi, Dario
AU - Falasca, Nicola Walter
AU - Koch, Giacomo
AU - Cagnin, Annachiara
AU - Nobili, Flavio
AU - Babiloni, Claudio
AU - Borroni, Barbara
AU - Padovani, Alessandro
AU - Onofrj, Marco
AU - Franciotti, Raffaella
N1 - Publisher Copyright:
© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com.
Copyright:
This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine
PY - 2021/1/1
Y1 - 2021/1/1
N2 - We investigated in a longitudinal multicenter cohort study functional cortical connectivity changes along the course of frontotemporal dementia (FTD) and Alzheimer's disease (AD) from the prodromal stage of the diseases. Electroencephalography (EEG) was recorded in 18 FTD and 18 AD patients at the prodromal stage of dementia, at dementia onset, and 3 years after dementia onset. Twenty healthy controls (HC) underwent EEG recordings at the same time interval as the patients. Mutual information (MI) analysis measured the strength of functional network connectivity. FTD and AD patients showed greater MI at the prodromal stage of dementia (FTD vs. HC P = 2 × 10-8; AD vs. HC P = 4 × 10-3). Local connectivity was higher in left and right frontal areas of FTD (P = 7 × 10-5 and 0.03) and in left and right posterior areas in AD (P = 3 × 10-5 and 5 × 10-5) versus HC. We showed cortical hyperconnectivity at the prodromal stage of dementia in areas involved in the specific pathological process of FTD (frontal regions) and AD (posterior regions). Hyperconnectivity disappeared during follow-up, thus suggesting that it is an early electrophysiological feature of dementia, potentially useful to identify prodromal FTD and AD.
AB - We investigated in a longitudinal multicenter cohort study functional cortical connectivity changes along the course of frontotemporal dementia (FTD) and Alzheimer's disease (AD) from the prodromal stage of the diseases. Electroencephalography (EEG) was recorded in 18 FTD and 18 AD patients at the prodromal stage of dementia, at dementia onset, and 3 years after dementia onset. Twenty healthy controls (HC) underwent EEG recordings at the same time interval as the patients. Mutual information (MI) analysis measured the strength of functional network connectivity. FTD and AD patients showed greater MI at the prodromal stage of dementia (FTD vs. HC P = 2 × 10-8; AD vs. HC P = 4 × 10-3). Local connectivity was higher in left and right frontal areas of FTD (P = 7 × 10-5 and 0.03) and in left and right posterior areas in AD (P = 3 × 10-5 and 5 × 10-5) versus HC. We showed cortical hyperconnectivity at the prodromal stage of dementia in areas involved in the specific pathological process of FTD (frontal regions) and AD (posterior regions). Hyperconnectivity disappeared during follow-up, thus suggesting that it is an early electrophysiological feature of dementia, potentially useful to identify prodromal FTD and AD.
KW - Alzheimer’s disease
KW - EEG
KW - frontotemporal dementia
KW - hyperconnectivity
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U2 - 10.1093/cercor/bhaa209
DO - 10.1093/cercor/bhaa209
M3 - Article
C2 - 32797208
AN - SCOPUS:85098466458
VL - 31
SP - 97
EP - 105
JO - Cerebral Cortex
JF - Cerebral Cortex
SN - 1047-3211
IS - 1
ER -