Hyperglycaemia and β-cell antibodies: Is it always pre-type 1 diabetes?

Giuseppe D'Annunzio; Marta Marchi; Concetta Aloi; Alessandro Salina; Francesca Lugani; Renata Lorini

doi:10.1016/j.diabres.2013.01.003

Hyperglycaemia and β-cell antibodies: Is it always pre-type 1 diabetes?

Giuseppe D'Annunzio, Marta Marchi, Concetta Aloi, Alessandro Salina, Francesca Lugani, Renata Lorini

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article › peer-review

Abstract

We describe 10-year-old girl with mild incidental hyperglycaemia, impaired glucose tolerance and GADA positivity. Family history for mild hyperglycaemia and GADA fluctuation alerted us to a possible MODY diagnosis which was confirmed by detection of GCK mutation c.626C>T; p.T209M. Weak or transient β-cell autoimmunity should not preclude genetic testing for MODY when the clinical features are suggestive.

Original language	English
Journal	Diabetes Research and Clinical Practice
Volume	100
Issue number	1
DOIs	https://doi.org/10.1016/j.diabres.2013.01.003
Publication status	Published - Apr 2013

Keywords

β-Cell antibodies
Hyperglycaemia
MODY
Pre-type 1 diabetes

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Internal Medicine
Endocrinology

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10.1016/j.diabres.2013.01.003

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title = "Hyperglycaemia and β-cell antibodies: Is it always pre-type 1 diabetes?",

abstract = "We describe 10-year-old girl with mild incidental hyperglycaemia, impaired glucose tolerance and GADA positivity. Family history for mild hyperglycaemia and GADA fluctuation alerted us to a possible MODY diagnosis which was confirmed by detection of GCK mutation c.626C>T; p.T209M. Weak or transient β-cell autoimmunity should not preclude genetic testing for MODY when the clinical features are suggestive.",

keywords = "β-Cell antibodies, Hyperglycaemia, MODY, Pre-type 1 diabetes",

author = "Giuseppe D'Annunzio and Marta Marchi and Concetta Aloi and Alessandro Salina and Francesca Lugani and Renata Lorini",

year = "2013",

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language = "English",

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journal = "Diabetes Research and Clinical Practice",

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AU - D'Annunzio, Giuseppe

AU - Marchi, Marta

AU - Aloi, Concetta

AU - Salina, Alessandro

AU - Lugani, Francesca

AU - Lorini, Renata

PY - 2013/4

Y1 - 2013/4

N2 - We describe 10-year-old girl with mild incidental hyperglycaemia, impaired glucose tolerance and GADA positivity. Family history for mild hyperglycaemia and GADA fluctuation alerted us to a possible MODY diagnosis which was confirmed by detection of GCK mutation c.626C>T; p.T209M. Weak or transient β-cell autoimmunity should not preclude genetic testing for MODY when the clinical features are suggestive.

AB - We describe 10-year-old girl with mild incidental hyperglycaemia, impaired glucose tolerance and GADA positivity. Family history for mild hyperglycaemia and GADA fluctuation alerted us to a possible MODY diagnosis which was confirmed by detection of GCK mutation c.626C>T; p.T209M. Weak or transient β-cell autoimmunity should not preclude genetic testing for MODY when the clinical features are suggestive.

KW - β-Cell antibodies

KW - Hyperglycaemia

KW - MODY

KW - Pre-type 1 diabetes

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Hyperglycaemia and β-cell antibodies: Is it always pre-type 1 diabetes?

Abstract

Keywords

ASJC Scopus subject areas

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