Hyperglycemia-conditioned increase in alpha-2-macroglobulin in healthy normal subjects: A phenomenon correlated with deficient antithrombin III activity

Antonio Ceriello, Antonio Quatraro, Patrizia Dello Russo, Egidio Marchi, Miriam Barbanti, Dario Giugliano

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Induced hyperglycemia in normal subjects increases α2-macroglobulin (α2M) activity and α2M concentration and reduces antithrombin III (ATIII) activity, while it does not affect ATIII plasma concentration. Hyperglycemia-determined variations in ATIII activity and α2M molecules are correlated in an inverse and parallel fashion. A compensatory role for the increase in α2M in the regulation of the coagulation system may be hypothesized. Moreover, these data provide evidence that hyperglycemia may decrease, directly, the biological function of some proteins and may influence the levels of some risk factors for the development of complications in diabetes.

Original languageEnglish
Pages (from-to)61-63
Number of pages3
JournalActa Haematologica
Volume82
Issue number2
DOIs
Publication statusPublished - 1989

Fingerprint

alpha-Macroglobulins
Macroglobulins
Antithrombin III
Hyperglycemia
Healthy Volunteers
Diabetes Complications
Proteins

Keywords

  • Antithrombin III
  • Decreased activity
  • Diabetes mellitus
  • Hyperglycemia
  • α<inf>2</inf>-Macroglobulin

ASJC Scopus subject areas

  • Hematology

Cite this

Hyperglycemia-conditioned increase in alpha-2-macroglobulin in healthy normal subjects : A phenomenon correlated with deficient antithrombin III activity. / Ceriello, Antonio; Quatraro, Antonio; Russo, Patrizia Dello; Marchi, Egidio; Barbanti, Miriam; Giugliano, Dario.

In: Acta Haematologica, Vol. 82, No. 2, 1989, p. 61-63.

Research output: Contribution to journalArticle

Ceriello, Antonio ; Quatraro, Antonio ; Russo, Patrizia Dello ; Marchi, Egidio ; Barbanti, Miriam ; Giugliano, Dario. / Hyperglycemia-conditioned increase in alpha-2-macroglobulin in healthy normal subjects : A phenomenon correlated with deficient antithrombin III activity. In: Acta Haematologica. 1989 ; Vol. 82, No. 2. pp. 61-63.
@article{07bbc0c2f60c4c8f9803fa39e88d4a17,
title = "Hyperglycemia-conditioned increase in alpha-2-macroglobulin in healthy normal subjects: A phenomenon correlated with deficient antithrombin III activity",
abstract = "Induced hyperglycemia in normal subjects increases α2-macroglobulin (α2M) activity and α2M concentration and reduces antithrombin III (ATIII) activity, while it does not affect ATIII plasma concentration. Hyperglycemia-determined variations in ATIII activity and α2M molecules are correlated in an inverse and parallel fashion. A compensatory role for the increase in α2M in the regulation of the coagulation system may be hypothesized. Moreover, these data provide evidence that hyperglycemia may decrease, directly, the biological function of some proteins and may influence the levels of some risk factors for the development of complications in diabetes.",
keywords = "Antithrombin III, Decreased activity, Diabetes mellitus, Hyperglycemia, α<inf>2</inf>-Macroglobulin",
author = "Antonio Ceriello and Antonio Quatraro and Russo, {Patrizia Dello} and Egidio Marchi and Miriam Barbanti and Dario Giugliano",
year = "1989",
doi = "10.1159/000205284",
language = "English",
volume = "82",
pages = "61--63",
journal = "Acta Haematologica",
issn = "0001-5792",
publisher = "S. Karger AG",
number = "2",

}

TY - JOUR

T1 - Hyperglycemia-conditioned increase in alpha-2-macroglobulin in healthy normal subjects

T2 - A phenomenon correlated with deficient antithrombin III activity

AU - Ceriello, Antonio

AU - Quatraro, Antonio

AU - Russo, Patrizia Dello

AU - Marchi, Egidio

AU - Barbanti, Miriam

AU - Giugliano, Dario

PY - 1989

Y1 - 1989

N2 - Induced hyperglycemia in normal subjects increases α2-macroglobulin (α2M) activity and α2M concentration and reduces antithrombin III (ATIII) activity, while it does not affect ATIII plasma concentration. Hyperglycemia-determined variations in ATIII activity and α2M molecules are correlated in an inverse and parallel fashion. A compensatory role for the increase in α2M in the regulation of the coagulation system may be hypothesized. Moreover, these data provide evidence that hyperglycemia may decrease, directly, the biological function of some proteins and may influence the levels of some risk factors for the development of complications in diabetes.

AB - Induced hyperglycemia in normal subjects increases α2-macroglobulin (α2M) activity and α2M concentration and reduces antithrombin III (ATIII) activity, while it does not affect ATIII plasma concentration. Hyperglycemia-determined variations in ATIII activity and α2M molecules are correlated in an inverse and parallel fashion. A compensatory role for the increase in α2M in the regulation of the coagulation system may be hypothesized. Moreover, these data provide evidence that hyperglycemia may decrease, directly, the biological function of some proteins and may influence the levels of some risk factors for the development of complications in diabetes.

KW - Antithrombin III

KW - Decreased activity

KW - Diabetes mellitus

KW - Hyperglycemia

KW - α<inf>2</inf>-Macroglobulin

UR - http://www.scopus.com/inward/record.url?scp=0024436482&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024436482&partnerID=8YFLogxK

U2 - 10.1159/000205284

DO - 10.1159/000205284

M3 - Article

C2 - 2477983

AN - SCOPUS:0024436482

VL - 82

SP - 61

EP - 63

JO - Acta Haematologica

JF - Acta Haematologica

SN - 0001-5792

IS - 2

ER -