Hyperglycemia following recovery from hypoglycemia worsens endothelial damage and thrombosis activation in type 1 diabetes and in healthy controls

A. Ceriello, A. Novials, E. Ortega, G. Pujadas, L. La Sala, R. Testa, A. R. Bonfigli, S. Genovese

Research output: Contribution to journalArticlepeer-review

Abstract

Background and aims: Hypoglycemia produces thrombosis activation, but little attention has been paid to the effects of hyperglycemia following recovery from hypoglycemia on thrombosis activation. Methods and results: In both twenty-two healthy subjects and twenty-one matched persons with type 1 diabetes, recovery from a 2-h induced hypoglycemia was obtained by reaching normo-glycemia or hyperglycemia for another 2h. After this, normal glycemia was maintained for the following 6h. Hyperglycemia after hypoglycemia was also repeated with the concomitant infusion of vitamin C. In both controls and people with diabetes, the recovery with normo-glycemia was accompanied by a significant improvement of Von Willebrand factor (vWF), prothrombin fragment 1+2 (F1+2), thrombin-antithrombin III-complexes (TAT), P-selectin, plasminogen activator inhibitor-1 (PAI-1), nitrotyrosine and 8-iso-prostaglandin F2α (8-iso-PGF2α) (p

Original languageEnglish
Pages (from-to)116-123
Number of pages8
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume24
Issue number2
DOIs
Publication statusPublished - 2014

Keywords

  • 8-iso-PGF2α
  • Hyperglycemia
  • Hypoglycemia
  • Oxidative stress
  • TAT
  • Thrombosis
  • VWFAc
  • VWFAg

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine

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