Hyperglycemia may determine fibrinopeptide A plasma level increase in humans

Antonio Ceriello; Dario Giugliano; Antonio Quatraro; Patrizia Dello Russo; Egidio Marchi; Roberto Torella

doi:10.1016/0026-0495(89)90152-2

Hyperglycemia may determine fibrinopeptide A plasma level increase in humans

Antonio Ceriello, Dario Giugliano, Antonio Quatraro, Patrizia Dello Russo, Egidio Marchi, Roberto Torella

IRCCS Multimedica

Research output: Contribution to journal › Article › peer-review

Abstract

The effects of hyperglycemia on plasma fibrinopeptide A (FPA) levels in normal subjects are reported. An increase of FPA concentration parallel to sustained hyperglycemia was observed; when the glycemia returned to basal values, FPA showed values in normal range. Heparin infusion was able to significantly decrease the hyperglycemia-induced augment of FPA levels. Isovolumic-isotonic NaCl solution infusion produced a slight (NS) increase in FPA levels; however, mild hyperglycemia, achieved by glucagon, was also able to produce a significant increase in FPA concentration. These data demonstrate the direct role of hyperglycemia in conditioning FPA level, and suggest that hyperglycemia, by itself, is a sufficient stimulus to produce thrombin activation in humans.

Original language	English
Pages (from-to)	1162-1163
Number of pages	2
Journal	Metabolism
Volume	38
Issue number	12
DOIs	https://doi.org/10.1016/0026-0495(89)90152-2
Publication status	Published - 1989

ASJC Scopus subject areas

Endocrinology
Endocrinology, Diabetes and Metabolism

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title = "Hyperglycemia may determine fibrinopeptide A plasma level increase in humans",

abstract = "The effects of hyperglycemia on plasma fibrinopeptide A (FPA) levels in normal subjects are reported. An increase of FPA concentration parallel to sustained hyperglycemia was observed; when the glycemia returned to basal values, FPA showed values in normal range. Heparin infusion was able to significantly decrease the hyperglycemia-induced augment of FPA levels. Isovolumic-isotonic NaCl solution infusion produced a slight (NS) increase in FPA levels; however, mild hyperglycemia, achieved by glucagon, was also able to produce a significant increase in FPA concentration. These data demonstrate the direct role of hyperglycemia in conditioning FPA level, and suggest that hyperglycemia, by itself, is a sufficient stimulus to produce thrombin activation in humans.",

author = "Antonio Ceriello and Dario Giugliano and Antonio Quatraro and Russo, {Patrizia Dello} and Egidio Marchi and Roberto Torella",

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T1 - Hyperglycemia may determine fibrinopeptide A plasma level increase in humans

AU - Ceriello, Antonio

AU - Giugliano, Dario

AU - Quatraro, Antonio

AU - Russo, Patrizia Dello

AU - Marchi, Egidio

AU - Torella, Roberto

PY - 1989

Y1 - 1989

N2 - The effects of hyperglycemia on plasma fibrinopeptide A (FPA) levels in normal subjects are reported. An increase of FPA concentration parallel to sustained hyperglycemia was observed; when the glycemia returned to basal values, FPA showed values in normal range. Heparin infusion was able to significantly decrease the hyperglycemia-induced augment of FPA levels. Isovolumic-isotonic NaCl solution infusion produced a slight (NS) increase in FPA levels; however, mild hyperglycemia, achieved by glucagon, was also able to produce a significant increase in FPA concentration. These data demonstrate the direct role of hyperglycemia in conditioning FPA level, and suggest that hyperglycemia, by itself, is a sufficient stimulus to produce thrombin activation in humans.

AB - The effects of hyperglycemia on plasma fibrinopeptide A (FPA) levels in normal subjects are reported. An increase of FPA concentration parallel to sustained hyperglycemia was observed; when the glycemia returned to basal values, FPA showed values in normal range. Heparin infusion was able to significantly decrease the hyperglycemia-induced augment of FPA levels. Isovolumic-isotonic NaCl solution infusion produced a slight (NS) increase in FPA levels; however, mild hyperglycemia, achieved by glucagon, was also able to produce a significant increase in FPA concentration. These data demonstrate the direct role of hyperglycemia in conditioning FPA level, and suggest that hyperglycemia, by itself, is a sufficient stimulus to produce thrombin activation in humans.

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