Hyperglycemia may determine fibrinopeptide A plasma level increase in humans

Antonio Ceriello, Dario Giugliano, Antonio Quatraro, Patrizia Dello Russo, Egidio Marchi, Roberto Torella

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of hyperglycemia on plasma fibrinopeptide A (FPA) levels in normal subjects are reported. An increase of FPA concentration parallel to sustained hyperglycemia was observed; when the glycemia returned to basal values, FPA showed values in normal range. Heparin infusion was able to significantly decrease the hyperglycemia-induced augment of FPA levels. Isovolumic-isotonic NaCl solution infusion produced a slight (NS) increase in FPA levels; however, mild hyperglycemia, achieved by glucagon, was also able to produce a significant increase in FPA concentration. These data demonstrate the direct role of hyperglycemia in conditioning FPA level, and suggest that hyperglycemia, by itself, is a sufficient stimulus to produce thrombin activation in humans.

Original languageEnglish
Pages (from-to)1162-1163
Number of pages2
JournalMetabolism
Volume38
Issue number12
DOIs
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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