Abstract
A variety of evidence suggest that cardiovascular system functions are impaired in altered gravity conditions [1]. We investigated the influence of a mild hypergravity environment (3g) on human primary endothelial cell viability, cell cycle and caveolin-1 expression. Even if we did not record changes in cell viability and apoptosis in the conditions studied, we found significant changes in cell cycle progression of primary endothelial cells exposed to hypergravity. These changes have been related to differentially expressed caveolin-1 gene, involved in the differentiation and cell cycle regulation. It is well known that caveolin-1 plays a crucial role in the organization of endothelial cells caveolae and that is expression is strictly linked with p42/p44 MAP kinase signal transduction cascade and with cell cycle regulation [2].
| Original language | English |
|---|---|
| Title of host publication | European Space Agency, (Special Publication) ESA SP |
| Pages | 325-326 |
| Number of pages | 2 |
| Edition | 501 |
| Publication status | Published - Sep 2002 |
| Event | Proceedings of the European Symposium on Life in Space for Life on Earth - Stockholm, Sweden Duration: Jun 2 2002 → Jun 7 2002 |
Other
| Other | Proceedings of the European Symposium on Life in Space for Life on Earth |
|---|---|
| Country | Sweden |
| City | Stockholm |
| Period | 6/2/02 → 6/7/02 |
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ASJC Scopus subject areas
- Aerospace Engineering
Cite this
Hypergravity affects cell cycle progression and caveolin-1 expression of in vitro cultured human primary endothelial cells. / Santi, Spartaco; Bianco, Maria Cristina; Blasi, Francesca; Spisni, Enzo; Riccio, Massimo; Toni, Mattia; Griffoni, Cristiana; Tomasi, Vittorio.
European Space Agency, (Special Publication) ESA SP. 501. ed. 2002. p. 325-326.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Hypergravity affects cell cycle progression and caveolin-1 expression of in vitro cultured human primary endothelial cells
AU - Santi, Spartaco
AU - Bianco, Maria Cristina
AU - Blasi, Francesca
AU - Spisni, Enzo
AU - Riccio, Massimo
AU - Toni, Mattia
AU - Griffoni, Cristiana
AU - Tomasi, Vittorio
PY - 2002/9
Y1 - 2002/9
N2 - A variety of evidence suggest that cardiovascular system functions are impaired in altered gravity conditions [1]. We investigated the influence of a mild hypergravity environment (3g) on human primary endothelial cell viability, cell cycle and caveolin-1 expression. Even if we did not record changes in cell viability and apoptosis in the conditions studied, we found significant changes in cell cycle progression of primary endothelial cells exposed to hypergravity. These changes have been related to differentially expressed caveolin-1 gene, involved in the differentiation and cell cycle regulation. It is well known that caveolin-1 plays a crucial role in the organization of endothelial cells caveolae and that is expression is strictly linked with p42/p44 MAP kinase signal transduction cascade and with cell cycle regulation [2].
AB - A variety of evidence suggest that cardiovascular system functions are impaired in altered gravity conditions [1]. We investigated the influence of a mild hypergravity environment (3g) on human primary endothelial cell viability, cell cycle and caveolin-1 expression. Even if we did not record changes in cell viability and apoptosis in the conditions studied, we found significant changes in cell cycle progression of primary endothelial cells exposed to hypergravity. These changes have been related to differentially expressed caveolin-1 gene, involved in the differentiation and cell cycle regulation. It is well known that caveolin-1 plays a crucial role in the organization of endothelial cells caveolae and that is expression is strictly linked with p42/p44 MAP kinase signal transduction cascade and with cell cycle regulation [2].
UR - http://www.scopus.com/inward/record.url?scp=0036770975&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036770975&partnerID=8YFLogxK
M3 - Conference contribution
SP - 325
EP - 326
BT - European Space Agency, (Special Publication) ESA SP
ER -