Hypergravity affects cell cycle progression and caveolin-1 expression of in vitro cultured human primary endothelial cells

Spartaco Santi; Maria Cristina Bianco; Francesca Blasi; Enzo Spisni; Massimo Riccio; Mattia Toni; Cristiana Griffoni; Vittorio Tomasi

Hypergravity affects cell cycle progression and caveolin-1 expression of in vitro cultured human primary endothelial cells

Spartaco Santi, Maria Cristina Bianco, Francesca Blasi, Enzo Spisni, Massimo Riccio, Mattia Toni, Cristiana Griffoni, Vittorio Tomasi

Istituti Ortopedici Rizzoli

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

A variety of evidence suggest that cardiovascular system functions are impaired in altered gravity conditions [1]. We investigated the influence of a mild hypergravity environment (3g) on human primary endothelial cell viability, cell cycle and caveolin-1 expression. Even if we did not record changes in cell viability and apoptosis in the conditions studied, we found significant changes in cell cycle progression of primary endothelial cells exposed to hypergravity. These changes have been related to differentially expressed caveolin-1 gene, involved in the differentiation and cell cycle regulation. It is well known that caveolin-1 plays a crucial role in the organization of endothelial cells caveolae and that is expression is strictly linked with p42/p44 MAP kinase signal transduction cascade and with cell cycle regulation [2].

Original language	English
Title of host publication	European Space Agency, (Special Publication) ESA SP
Pages	325-326
Number of pages	2
Edition	501
Publication status	Published - Sep 2002
Event	Proceedings of the European Symposium on Life in Space for Life on Earth - Stockholm, Sweden Duration: Jun 2 2002 → Jun 7 2002

Other

Other	Proceedings of the European Symposium on Life in Space for Life on Earth
Country	Sweden
City	Stockholm
Period	6/2/02 → 6/7/02

ASJC Scopus subject areas

Aerospace Engineering

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Hypergravity affects cell cycle progression and caveolin-1 expression of in vitro cultured human primary endothelial cells. / Santi, Spartaco; Bianco, Maria Cristina; Blasi, Francesca; Spisni, Enzo; Riccio, Massimo; Toni, Mattia; Griffoni, Cristiana; Tomasi, Vittorio.

European Space Agency, (Special Publication) ESA SP. 501. ed. 2002. p. 325-326.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Santi, S, Bianco, MC, Blasi, F, Spisni, E, Riccio, M, Toni, M, Griffoni, C & Tomasi, V 2002, Hypergravity affects cell cycle progression and caveolin-1 expression of in vitro cultured human primary endothelial cells. in European Space Agency, (Special Publication) ESA SP. 501 edn, pp. 325-326, Proceedings of the European Symposium on Life in Space for Life on Earth, Stockholm, Sweden, 6/2/02.

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abstract = "A variety of evidence suggest that cardiovascular system functions are impaired in altered gravity conditions [1]. We investigated the influence of a mild hypergravity environment (3g) on human primary endothelial cell viability, cell cycle and caveolin-1 expression. Even if we did not record changes in cell viability and apoptosis in the conditions studied, we found significant changes in cell cycle progression of primary endothelial cells exposed to hypergravity. These changes have been related to differentially expressed caveolin-1 gene, involved in the differentiation and cell cycle regulation. It is well known that caveolin-1 plays a crucial role in the organization of endothelial cells caveolae and that is expression is strictly linked with p42/p44 MAP kinase signal transduction cascade and with cell cycle regulation [2].",

author = "Spartaco Santi and Bianco, {Maria Cristina} and Francesca Blasi and Enzo Spisni and Massimo Riccio and Mattia Toni and Cristiana Griffoni and Vittorio Tomasi",

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AU - Santi, Spartaco

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AU - Blasi, Francesca

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AU - Riccio, Massimo

AU - Toni, Mattia

AU - Griffoni, Cristiana

AU - Tomasi, Vittorio

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N2 - A variety of evidence suggest that cardiovascular system functions are impaired in altered gravity conditions [1]. We investigated the influence of a mild hypergravity environment (3g) on human primary endothelial cell viability, cell cycle and caveolin-1 expression. Even if we did not record changes in cell viability and apoptosis in the conditions studied, we found significant changes in cell cycle progression of primary endothelial cells exposed to hypergravity. These changes have been related to differentially expressed caveolin-1 gene, involved in the differentiation and cell cycle regulation. It is well known that caveolin-1 plays a crucial role in the organization of endothelial cells caveolae and that is expression is strictly linked with p42/p44 MAP kinase signal transduction cascade and with cell cycle regulation [2].

AB - A variety of evidence suggest that cardiovascular system functions are impaired in altered gravity conditions [1]. We investigated the influence of a mild hypergravity environment (3g) on human primary endothelial cell viability, cell cycle and caveolin-1 expression. Even if we did not record changes in cell viability and apoptosis in the conditions studied, we found significant changes in cell cycle progression of primary endothelial cells exposed to hypergravity. These changes have been related to differentially expressed caveolin-1 gene, involved in the differentiation and cell cycle regulation. It is well known that caveolin-1 plays a crucial role in the organization of endothelial cells caveolae and that is expression is strictly linked with p42/p44 MAP kinase signal transduction cascade and with cell cycle regulation [2].

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