Hypergravity affects cell cycle progression and caveolin-1 expression of in vitro cultured human primary endothelial cells

Spartaco Santi, Maria Cristina Bianco, Francesca Blasi, Enzo Spisni, Massimo Riccio, Mattia Toni, Cristiana Griffoni, Vittorio Tomasi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A variety of evidence suggest that cardiovascular system functions are impaired in altered gravity conditions [1]. We investigated the influence of a mild hypergravity environment (3g) on human primary endothelial cell viability, cell cycle and caveolin-1 expression. Even if we did not record changes in cell viability and apoptosis in the conditions studied, we found significant changes in cell cycle progression of primary endothelial cells exposed to hypergravity. These changes have been related to differentially expressed caveolin-1 gene, involved in the differentiation and cell cycle regulation. It is well known that caveolin-1 plays a crucial role in the organization of endothelial cells caveolae and that is expression is strictly linked with p42/p44 MAP kinase signal transduction cascade and with cell cycle regulation [2].

Original languageEnglish
Title of host publicationEuropean Space Agency, (Special Publication) ESA SP
Pages325-326
Number of pages2
Edition501
Publication statusPublished - Sep 2002
EventProceedings of the European Symposium on Life in Space for Life on Earth - Stockholm, Sweden
Duration: Jun 2 2002Jun 7 2002

Other

OtherProceedings of the European Symposium on Life in Space for Life on Earth
CountrySweden
CityStockholm
Period6/2/026/7/02

ASJC Scopus subject areas

  • Aerospace Engineering

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    Santi, S., Bianco, M. C., Blasi, F., Spisni, E., Riccio, M., Toni, M., Griffoni, C., & Tomasi, V. (2002). Hypergravity affects cell cycle progression and caveolin-1 expression of in vitro cultured human primary endothelial cells. In European Space Agency, (Special Publication) ESA SP (501 ed., pp. 325-326)