Abstract
A variety of evidence suggest that cardiovascular system functions are impaired in altered gravity conditions [1]. In this study we investigated the influence of hypergravity environment (3g) on endothelial cell proliferation, endothelial vasoactive compound production and on in vitro angiogenesis. We found that cultured primary human endothial cells were very sensitive to mild hypergravity conditions. Even if we did not record changes in cell viability and apoptosis, we found significant differences in cell proliferation, prostacyclin (PGI2) synthesis, nitric oxide (NO) synthesis, and in angiogenic responses. Using western blotting technique we detected an increased expression of cycloxygenase-2 (COX-2) in primary endothelial cells exposed for 48 hours to hypergravity, in comparison to those exposed to normal gravity.
Original language | English |
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Title of host publication | European Space Agency, (Special Publication) ESA SP |
Pages | 327-328 |
Number of pages | 2 |
Edition | 501 |
Publication status | Published - Sep 2002 |
Event | Proceedings of the European Symposium on Life in Space for Life on Earth - Stockholm, Sweden Duration: Jun 2 2002 → Jun 7 2002 |
Other
Other | Proceedings of the European Symposium on Life in Space for Life on Earth |
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Country | Sweden |
City | Stockholm |
Period | 6/2/02 → 6/7/02 |
ASJC Scopus subject areas
- Aerospace Engineering