In the lost two decades, retrospective case-control studies and prospective cohort studies have demonstrated that moderate hyperhomocysteinemia is a frequent and independent risk factor for premature vascular disease in the coronary, cerebral and peripheral arteries. More recently, the association of moderate hyperhomocysteinemia with venous thrombosis has been shown. Genetic and environmental factors act in concert to cause moderate hyperhomocysteinemia. Since inadequate intake of folic acid, vitamin B12 or vitamin B6 are most frequently associated with hyperhomocysteinemia, particularly in the elderly, it is likely that dietary supplementation of these vitamins could have a tremendous impact on the epidemiology and natural history of thrombotic diseases.
|Number of pages||6|
|Journal||Annali Italiani di Medicina Interna|
|Publication status||Published - 1997|
ASJC Scopus subject areas
- Internal Medicine