Iperomocisteinemia nei pazienti uremici: effetti della supplementazione alternata di acido folico e vitamina B 12.

Translated title of the contribution: Hyperhomocysteinemia and alternate vitamin supplementation

S. De Angelis, A. Noce, M. Dessì, A. Pastore, F. Scaccia, M. Trombetta, C. Tozzo, G. Splendiani

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Treatment with folic acid and vitamin B 12 appears to be effective in lowering total plasma Homocysteine (tHcy) concentration, but whether vitamin B 12 alone decreases tHcy in patients with normal vitamin B 12 status is still unknown. The aims of the present study were to explore the effect of alternate vitamin supplementation with folic acid or vitamin B 12 on tHcy concentrations in haemodialysis (HD) patients, and to compare changes in tHcy concentrations with MTHFR genotype. METHODS: 74 patients, 44 men and 30 women, were recruited and randomized blindly into two groups of 37 subjects each. The first group was initially treated with vitamin B 12 for two months, and with folic acid for the following two months; the second group was supplemented in the reverse order. In both groups the treatment was followed by a 2-month washout period. tHcy levels were measured at the beginning of treatment (T0), after two months (T1), four months (T2), and at the end of the washout period (T3). Vitamin B 12 and folate were taken at T0 and T3. RESULTS: The genotype frequency was: C/C 37%, C/T 34%, T/T 29%. tHcy decreased in both groups following the alternate vitamins therapy. This decrease was greater for the T/T genotype (p

Translated title of the contributionHyperhomocysteinemia and alternate vitamin supplementation
Original languageItalian
Pages (from-to)51-55
Number of pages5
JournalGiornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia
Volume24
Issue number1
Publication statusPublished - Jan 2007

ASJC Scopus subject areas

  • Nephrology

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