Hyperhomocysteinemia and C677T MTHFR genotype in patients with retinal vein thrombosis

Gianluca Sottilotta, Simona Maria Siboni, Caterina Latella, Vincenzo Oriana, Ermelinda Romeo, Rita Santoro, Dario Consonni, Vincenzo Trapani Lombardo

Research output: Contribution to journalArticle

Abstract

Introduction: Elevated homocysteine (Hcy) is associated with the risk of deep vein thrombosis, pulmonary embolism, ischemic heart disease, and stroke. Several studies have suggested that hyperhomocysteinemia (HHcy) may predispose to retinal vein thrombosis (RVT) development. The aim of this study is to investigate the relationship between Hcy, C677T methylenetetrahydrofolate reductase (MTHFR) genotype, and RVT in patients compared with controls. Materials and Methods: We evaluated the Hcy plasma level of 3114 consecutive participants in 2 Italian centers during a 2-year period. Hyperhomocysteinemia was found in 99 patients and 136 healthy participants. Of the 99 patients, 20 had RVT with a high prevalence of HHcy in the RVT subgroup (20.2%). This result suggested a possible relationship between HHcy and RVT development. We investigated 105 consecutive patients with recent diagnosis of RVT, and we compared them with 226 healthy controls to evaluate whether HHcy may be a risk factor for RVT. Results: the prevalence of HHcy was higher in patients compared with controls (34.3% vs 14.2%; P

Original languageEnglish
Pages (from-to)549-553
Number of pages5
JournalClinical and Applied Thrombosis/Hemostasis
Volume16
Issue number5
DOIs
Publication statusPublished - Oct 2010

Keywords

  • Gene polymorphisms
  • Thrombophilia
  • Venous thromboembolism

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Hyperhomocysteinemia and C677T MTHFR genotype in patients with retinal vein thrombosis'. Together they form a unique fingerprint.

  • Cite this

    Sottilotta, G., Siboni, S. M., Latella, C., Oriana, V., Romeo, E., Santoro, R., Consonni, D., & Lombardo, V. T. (2010). Hyperhomocysteinemia and C677T MTHFR genotype in patients with retinal vein thrombosis. Clinical and Applied Thrombosis/Hemostasis, 16(5), 549-553. https://doi.org/10.1177/1076029609348644