Hyperhomocysteinemia and other thrombophilic risk factors in 26 patients with cerebral venous thrombosis

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Despite the continuous description of new conditions pre-disposing for cerebral venous thrombosis (CVT), no apparent cause is found in about 30% of cases. Hyperhomocysteinemia (hyper-Hcy) is an established risk factor for deep venous thrombosis and stroke but has not been clearly associated with increased risk of CVT. We assessed the prevalence of hyper-Hcy and other thrombophilic risk factors in a population of 26 consecutive patients with non-pyogenic CVT, by review of a prospectively maintained database. The prevalences of hyper-Hcy and prothrombin G20210A, factor V G1691A and methylenetetrahydrofolate reductase (MTHFR) C677T mutations in these patients were compared with those in 100 healthy controls and 100 patients with cerebroarterial disease. The prevalence of hyper-Hcy was greater in patients with CVT (10/26, 38.5%) than healthy controls (13/100; OR 4.18, 95% CI 1.58-11.16) and comparable with that in patients with cerebroarterial disease (42/100). No significant differences were found in the prevalences of prothrombin or MTHFR mutation. No factor V mutation was found. Our findings indicate that hyper-Hcy is associated with an increased risk of CVT. Additional prospective cohort studies on large series of patients are required to clarify the time relationship between hyper-Hcy and the thrombotic event.

Original languageEnglish
Pages (from-to)405-409
Number of pages5
JournalEuropean Journal of Neurology
Issue number6
Publication statusPublished - Jun 2004


  • Cerebral venous thrombosis
  • Hyperhomocysteinemia
  • Leiden factor
  • Methylenetetrahydrofolate reductase
  • Prothrombin

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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