Hyperhomocysteinemia and retinal vascular changes in patients with epilepsy

Vincenzo Belcastro, Pasquale Striano, Daniela Caccamo, Cinzia Costa, Laura Rosa Pisani, Costantino John Trombetta, Aldo Maddaloni, Clotilde Ciampa, Raffaele Reccia, Riccardo Ientile, Salvatore Striano, Paolo Calabresi, Francesco Pisani

Research output: Contribution to journalArticlepeer-review


The possible occurrence of asymptomatic retinal vascular damage was investigated in 87 hyperhomocysteinemic (plasma total homocysteine >13 μmol/L) adult epileptic patients (46 M, 41 F; age 34.2 ± 7.5 years; mean plasma homocysteine levels 29.8 ± 15.4 μmol/L; duration of epilepsy 11.5 ± 2.4 years) with no other risk factors for atherosclerosis. Plasma total homocysteine (t-Hcy) levels were assayed by high performance liquid chromatography. Retina vascular status was assessed by fundus oculi ophthalmoscopy performed in blind conditions by two skilled ophthalmologists and compared with that obtained from 102 randomly chosen epileptic patients and 94 healthy subjects, matched for age and sex, showing normal t-Hcy levels. No retina abnormality was detected in any of the subjects belonging to the three groups. Based on these results, we conclude that epileptic patients with mild to intermediate hyperhomocysteinemia are not at risk to develop retinal vascular disease.

Original languageEnglish
Pages (from-to)86-89
Number of pages4
JournalEpilepsy Research
Issue number1
Publication statusPublished - Sep 2008


  • Atherosclerosis
  • Homocysteine
  • Retinopathy

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neurology


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