Hyperhomocysteinemia as an early predictor of erectile dysfunction

International index of erectile function (IIEF) and penile doppler ultrasound correlation with plasma levels of homocysteine

Riccardo Giovannone, Gian Maria Busetto, Gabriele Antonini, Ottavio De Cobelli, Matteo Ferro, Stefano Tricarico, Francesco Del Giudice, Giulia Ragonesi, Simon L. Conti, Giuseppe Lucarelli, Vincenzo Gentile, Ettore De Berardinis

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Erectile dysfunction (ED) is inability to achieve and maintain an erection to permit satisfactory sexual activity. Homocysteine (Hcys) is a sulfur-containing amino acid synthesized from the essential amino acid methionine. Experimental models have elucidated the role of hyperhomocysteinemia (HHcys) as a strong and independent predictor for atherosclerosis progression and impaired cavernosal perfusion. The aim of this study is to investigate the serum levels of Hcys in our cohort of patients with ED, to compare these values with these of control population and to examine Hcys as a predictive marker for those patients who are beginning to complain mild-moderate ED. A total of 431 patients were enrolled in the study. The whole cohort was asked to complete the International Index of Erectile Function (IIEF) questionnaire. The study population was divided in 3 main groups: Group A: 145 patients with no ED serving as a control group; Group B: 145 patients with mild or mild-moderate ED; Group C: 141 patients with moderate or severe ED. Each participant underwent blood analysis. All patients underwent baseline and dynamic penile Doppler ultrasonography. We found in our cohort mean Hcys plasma concentrations significantly higher than the cut-off point in both groups B and C (18.6±4.7 and 28.38±7.8, respectively). Mean IIEF score was 27.9±1.39, 19.5±2.6, and 11.1±2.5 for groups A, B, and C, respectively (P

Original languageEnglish
Pages (from-to)e1556
JournalMedicine (United States)
Volume94
Issue number39
DOIs
Publication statusPublished - 2015

Fingerprint

Doppler Ultrasonography
Hyperhomocysteinemia
Homocysteine
Erectile Dysfunction
Sulfur Amino Acids
Essential Amino Acids
Sexual Behavior
Methionine
Population
Atherosclerosis
Theoretical Models
Perfusion
Control Groups
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hyperhomocysteinemia as an early predictor of erectile dysfunction : International index of erectile function (IIEF) and penile doppler ultrasound correlation with plasma levels of homocysteine. / Giovannone, Riccardo; Busetto, Gian Maria; Antonini, Gabriele; De Cobelli, Ottavio; Ferro, Matteo; Tricarico, Stefano; Del Giudice, Francesco; Ragonesi, Giulia; Conti, Simon L.; Lucarelli, Giuseppe; Gentile, Vincenzo; De Berardinis, Ettore.

In: Medicine (United States), Vol. 94, No. 39, 2015, p. e1556.

Research output: Contribution to journalArticle

Giovannone, Riccardo ; Busetto, Gian Maria ; Antonini, Gabriele ; De Cobelli, Ottavio ; Ferro, Matteo ; Tricarico, Stefano ; Del Giudice, Francesco ; Ragonesi, Giulia ; Conti, Simon L. ; Lucarelli, Giuseppe ; Gentile, Vincenzo ; De Berardinis, Ettore. / Hyperhomocysteinemia as an early predictor of erectile dysfunction : International index of erectile function (IIEF) and penile doppler ultrasound correlation with plasma levels of homocysteine. In: Medicine (United States). 2015 ; Vol. 94, No. 39. pp. e1556.
@article{77ce0369eda94c2882899dac8013f0d5,
title = "Hyperhomocysteinemia as an early predictor of erectile dysfunction: International index of erectile function (IIEF) and penile doppler ultrasound correlation with plasma levels of homocysteine",
abstract = "Erectile dysfunction (ED) is inability to achieve and maintain an erection to permit satisfactory sexual activity. Homocysteine (Hcys) is a sulfur-containing amino acid synthesized from the essential amino acid methionine. Experimental models have elucidated the role of hyperhomocysteinemia (HHcys) as a strong and independent predictor for atherosclerosis progression and impaired cavernosal perfusion. The aim of this study is to investigate the serum levels of Hcys in our cohort of patients with ED, to compare these values with these of control population and to examine Hcys as a predictive marker for those patients who are beginning to complain mild-moderate ED. A total of 431 patients were enrolled in the study. The whole cohort was asked to complete the International Index of Erectile Function (IIEF) questionnaire. The study population was divided in 3 main groups: Group A: 145 patients with no ED serving as a control group; Group B: 145 patients with mild or mild-moderate ED; Group C: 141 patients with moderate or severe ED. Each participant underwent blood analysis. All patients underwent baseline and dynamic penile Doppler ultrasonography. We found in our cohort mean Hcys plasma concentrations significantly higher than the cut-off point in both groups B and C (18.6±4.7 and 28.38±7.8, respectively). Mean IIEF score was 27.9±1.39, 19.5±2.6, and 11.1±2.5 for groups A, B, and C, respectively (P",
author = "Riccardo Giovannone and Busetto, {Gian Maria} and Gabriele Antonini and {De Cobelli}, Ottavio and Matteo Ferro and Stefano Tricarico and {Del Giudice}, Francesco and Giulia Ragonesi and Conti, {Simon L.} and Giuseppe Lucarelli and Vincenzo Gentile and {De Berardinis}, Ettore",
year = "2015",
doi = "10.1097/MD.0000000000001556",
language = "English",
volume = "94",
pages = "e1556",
journal = "Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries",
issn = "0025-7974",
publisher = "Lippincott Williams and Wilkins",
number = "39",

}

TY - JOUR

T1 - Hyperhomocysteinemia as an early predictor of erectile dysfunction

T2 - International index of erectile function (IIEF) and penile doppler ultrasound correlation with plasma levels of homocysteine

AU - Giovannone, Riccardo

AU - Busetto, Gian Maria

AU - Antonini, Gabriele

AU - De Cobelli, Ottavio

AU - Ferro, Matteo

AU - Tricarico, Stefano

AU - Del Giudice, Francesco

AU - Ragonesi, Giulia

AU - Conti, Simon L.

AU - Lucarelli, Giuseppe

AU - Gentile, Vincenzo

AU - De Berardinis, Ettore

PY - 2015

Y1 - 2015

N2 - Erectile dysfunction (ED) is inability to achieve and maintain an erection to permit satisfactory sexual activity. Homocysteine (Hcys) is a sulfur-containing amino acid synthesized from the essential amino acid methionine. Experimental models have elucidated the role of hyperhomocysteinemia (HHcys) as a strong and independent predictor for atherosclerosis progression and impaired cavernosal perfusion. The aim of this study is to investigate the serum levels of Hcys in our cohort of patients with ED, to compare these values with these of control population and to examine Hcys as a predictive marker for those patients who are beginning to complain mild-moderate ED. A total of 431 patients were enrolled in the study. The whole cohort was asked to complete the International Index of Erectile Function (IIEF) questionnaire. The study population was divided in 3 main groups: Group A: 145 patients with no ED serving as a control group; Group B: 145 patients with mild or mild-moderate ED; Group C: 141 patients with moderate or severe ED. Each participant underwent blood analysis. All patients underwent baseline and dynamic penile Doppler ultrasonography. We found in our cohort mean Hcys plasma concentrations significantly higher than the cut-off point in both groups B and C (18.6±4.7 and 28.38±7.8, respectively). Mean IIEF score was 27.9±1.39, 19.5±2.6, and 11.1±2.5 for groups A, B, and C, respectively (P

AB - Erectile dysfunction (ED) is inability to achieve and maintain an erection to permit satisfactory sexual activity. Homocysteine (Hcys) is a sulfur-containing amino acid synthesized from the essential amino acid methionine. Experimental models have elucidated the role of hyperhomocysteinemia (HHcys) as a strong and independent predictor for atherosclerosis progression and impaired cavernosal perfusion. The aim of this study is to investigate the serum levels of Hcys in our cohort of patients with ED, to compare these values with these of control population and to examine Hcys as a predictive marker for those patients who are beginning to complain mild-moderate ED. A total of 431 patients were enrolled in the study. The whole cohort was asked to complete the International Index of Erectile Function (IIEF) questionnaire. The study population was divided in 3 main groups: Group A: 145 patients with no ED serving as a control group; Group B: 145 patients with mild or mild-moderate ED; Group C: 141 patients with moderate or severe ED. Each participant underwent blood analysis. All patients underwent baseline and dynamic penile Doppler ultrasonography. We found in our cohort mean Hcys plasma concentrations significantly higher than the cut-off point in both groups B and C (18.6±4.7 and 28.38±7.8, respectively). Mean IIEF score was 27.9±1.39, 19.5±2.6, and 11.1±2.5 for groups A, B, and C, respectively (P

UR - http://www.scopus.com/inward/record.url?scp=84943162444&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84943162444&partnerID=8YFLogxK

U2 - 10.1097/MD.0000000000001556

DO - 10.1097/MD.0000000000001556

M3 - Article

VL - 94

SP - e1556

JO - Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries

JF - Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries

SN - 0025-7974

IS - 39

ER -