Abstract
Erectile dysfunction (ED) is inability to achieve and maintain an erection to permit satisfactory sexual activity. Homocysteine (Hcys) is a sulfur-containing amino acid synthesized from the essential amino acid methionine. Experimental models have elucidated the role of hyperhomocysteinemia (HHcys) as a strong and independent predictor for atherosclerosis progression and impaired cavernosal perfusion. The aim of this study is to investigate the serum levels of Hcys in our cohort of patients with ED, to compare these values with these of control population and to examine Hcys as a predictive marker for those patients who are beginning to complain mild-moderate ED. A total of 431 patients were enrolled in the study. The whole cohort was asked to complete the International Index of Erectile Function (IIEF) questionnaire. The study population was divided in 3 main groups: Group A: 145 patients with no ED serving as a control group; Group B: 145 patients with mild or mild-moderate ED; Group C: 141 patients with moderate or severe ED. Each participant underwent blood analysis. All patients underwent baseline and dynamic penile Doppler ultrasonography. We found in our cohort mean Hcys plasma concentrations significantly higher than the cut-off point in both groups B and C (18.6±4.7 and 28.38±7.8, respectively). Mean IIEF score was 27.9±1.39, 19.5±2.6, and 11.1±2.5 for groups A, B, and C, respectively (P
| Original language | English |
|---|---|
| Pages (from-to) | e1556 |
| Journal | Medicine (United States) |
| Volume | 94 |
| Issue number | 39 |
| DOIs | |
| Publication status | Published - 2015 |
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ASJC Scopus subject areas
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Hyperhomocysteinemia as an early predictor of erectile dysfunction : International index of erectile function (IIEF) and penile doppler ultrasound correlation with plasma levels of homocysteine. / Giovannone, Riccardo; Busetto, Gian Maria; Antonini, Gabriele; De Cobelli, Ottavio; Ferro, Matteo; Tricarico, Stefano; Del Giudice, Francesco; Ragonesi, Giulia; Conti, Simon L.; Lucarelli, Giuseppe; Gentile, Vincenzo; De Berardinis, Ettore.
In: Medicine (United States), Vol. 94, No. 39, 2015, p. e1556.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hyperhomocysteinemia as an early predictor of erectile dysfunction
T2 - International index of erectile function (IIEF) and penile doppler ultrasound correlation with plasma levels of homocysteine
AU - Giovannone, Riccardo
AU - Busetto, Gian Maria
AU - Antonini, Gabriele
AU - De Cobelli, Ottavio
AU - Ferro, Matteo
AU - Tricarico, Stefano
AU - Del Giudice, Francesco
AU - Ragonesi, Giulia
AU - Conti, Simon L.
AU - Lucarelli, Giuseppe
AU - Gentile, Vincenzo
AU - De Berardinis, Ettore
PY - 2015
Y1 - 2015
N2 - Erectile dysfunction (ED) is inability to achieve and maintain an erection to permit satisfactory sexual activity. Homocysteine (Hcys) is a sulfur-containing amino acid synthesized from the essential amino acid methionine. Experimental models have elucidated the role of hyperhomocysteinemia (HHcys) as a strong and independent predictor for atherosclerosis progression and impaired cavernosal perfusion. The aim of this study is to investigate the serum levels of Hcys in our cohort of patients with ED, to compare these values with these of control population and to examine Hcys as a predictive marker for those patients who are beginning to complain mild-moderate ED. A total of 431 patients were enrolled in the study. The whole cohort was asked to complete the International Index of Erectile Function (IIEF) questionnaire. The study population was divided in 3 main groups: Group A: 145 patients with no ED serving as a control group; Group B: 145 patients with mild or mild-moderate ED; Group C: 141 patients with moderate or severe ED. Each participant underwent blood analysis. All patients underwent baseline and dynamic penile Doppler ultrasonography. We found in our cohort mean Hcys plasma concentrations significantly higher than the cut-off point in both groups B and C (18.6±4.7 and 28.38±7.8, respectively). Mean IIEF score was 27.9±1.39, 19.5±2.6, and 11.1±2.5 for groups A, B, and C, respectively (P
AB - Erectile dysfunction (ED) is inability to achieve and maintain an erection to permit satisfactory sexual activity. Homocysteine (Hcys) is a sulfur-containing amino acid synthesized from the essential amino acid methionine. Experimental models have elucidated the role of hyperhomocysteinemia (HHcys) as a strong and independent predictor for atherosclerosis progression and impaired cavernosal perfusion. The aim of this study is to investigate the serum levels of Hcys in our cohort of patients with ED, to compare these values with these of control population and to examine Hcys as a predictive marker for those patients who are beginning to complain mild-moderate ED. A total of 431 patients were enrolled in the study. The whole cohort was asked to complete the International Index of Erectile Function (IIEF) questionnaire. The study population was divided in 3 main groups: Group A: 145 patients with no ED serving as a control group; Group B: 145 patients with mild or mild-moderate ED; Group C: 141 patients with moderate or severe ED. Each participant underwent blood analysis. All patients underwent baseline and dynamic penile Doppler ultrasonography. We found in our cohort mean Hcys plasma concentrations significantly higher than the cut-off point in both groups B and C (18.6±4.7 and 28.38±7.8, respectively). Mean IIEF score was 27.9±1.39, 19.5±2.6, and 11.1±2.5 for groups A, B, and C, respectively (P
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U2 - 10.1097/MD.0000000000001556
DO - 10.1097/MD.0000000000001556
M3 - Article
VL - 94
SP - e1556
JO - Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries
JF - Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries
SN - 0025-7974
IS - 39
ER -