Hyperhomocysteinemia in levodopa-treated patients with Parkinson's disease Dementia

Stefano Zoccolella, Claudia dell'Aquila, Giovanni Abruzzese, Angelo Antonini, Ubaldo Bonuccelli, Margherita Canesi, Silvano Cristina, Roberta Marchese, Claudio Pacchetti, Roberto Zagaglia, Giancarlo Logroscino, Giovanni Defazio, Paolo Lamberti, Paolo Livera

Research output: Contribution to journalArticle

Abstract

Dementia is a frequent non-motor feature of Parkinson's disease (PD). Elevated plasma homocysteine (Hcy) levels have been associated with both cognitive impairment and dementia. Increased Hcy levels have been observed in levodopa-treated patients with PD. The objective of our study was to evaluate the association between plasma Hcy levels and dementia in PD. We performed a multicenter cross-sectional study on patients with PD with (PDD) and without (PDnD) dementia and age- and sex-matched healthy controls. We compared Hcy levels in patients with PDD and PDnD and healthy controls, and we performed logistic regression analysis to search for an association between the presence of dementia and increased Hcy levels in PD. Patients with PD (121), PDD (42), and PDnD (79), and age-and sex-matched controls (154) were enrolled. Hcy levels were higher in patients with PD compared to controls (17.5 μmol (/L ± 10.2 vs. 11 ± 4.1; P <0.00001). Among patients with PD, Hcy levels were higher in the PDD group compared to the PDnD group (20.7 μmol/L ± 12.1 vs. 15.8 ± 8.5; P 5 0.002). In a multivariate logistic regression model, higher Hcy levels [Odds ratios comparing the top (>18.9 μmol/L) with the bottom tertile (

Original languageEnglish
Pages (from-to)1028-1033
Number of pages6
JournalMovement Disorders
Volume24
Issue number7
DOIs
Publication statusPublished - May 15 2009

Fingerprint

Hyperhomocysteinemia
Levodopa
Homocysteine
Parkinson Disease
Dementia
Cross-Sectional Studies
Logistic Models
Regression Analysis

Keywords

  • Dementia
  • Folate
  • Homocysteine
  • Parkinson's disease
  • Progression

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Zoccolella, S., dell'Aquila, C., Abruzzese, G., Antonini, A., Bonuccelli, U., Canesi, M., ... Livera, P. (2009). Hyperhomocysteinemia in levodopa-treated patients with Parkinson's disease Dementia. Movement Disorders, 24(7), 1028-1033. https://doi.org/10.1002/mds.22511

Hyperhomocysteinemia in levodopa-treated patients with Parkinson's disease Dementia. / Zoccolella, Stefano; dell'Aquila, Claudia; Abruzzese, Giovanni; Antonini, Angelo; Bonuccelli, Ubaldo; Canesi, Margherita; Cristina, Silvano; Marchese, Roberta; Pacchetti, Claudio; Zagaglia, Roberto; Logroscino, Giancarlo; Defazio, Giovanni; Lamberti, Paolo; Livera, Paolo.

In: Movement Disorders, Vol. 24, No. 7, 15.05.2009, p. 1028-1033.

Research output: Contribution to journalArticle

Zoccolella, S, dell'Aquila, C, Abruzzese, G, Antonini, A, Bonuccelli, U, Canesi, M, Cristina, S, Marchese, R, Pacchetti, C, Zagaglia, R, Logroscino, G, Defazio, G, Lamberti, P & Livera, P 2009, 'Hyperhomocysteinemia in levodopa-treated patients with Parkinson's disease Dementia', Movement Disorders, vol. 24, no. 7, pp. 1028-1033. https://doi.org/10.1002/mds.22511
Zoccolella S, dell'Aquila C, Abruzzese G, Antonini A, Bonuccelli U, Canesi M et al. Hyperhomocysteinemia in levodopa-treated patients with Parkinson's disease Dementia. Movement Disorders. 2009 May 15;24(7):1028-1033. https://doi.org/10.1002/mds.22511
Zoccolella, Stefano ; dell'Aquila, Claudia ; Abruzzese, Giovanni ; Antonini, Angelo ; Bonuccelli, Ubaldo ; Canesi, Margherita ; Cristina, Silvano ; Marchese, Roberta ; Pacchetti, Claudio ; Zagaglia, Roberto ; Logroscino, Giancarlo ; Defazio, Giovanni ; Lamberti, Paolo ; Livera, Paolo. / Hyperhomocysteinemia in levodopa-treated patients with Parkinson's disease Dementia. In: Movement Disorders. 2009 ; Vol. 24, No. 7. pp. 1028-1033.
@article{2dccd97acf0943dbbb2cbdde6efa02f7,
title = "Hyperhomocysteinemia in levodopa-treated patients with Parkinson's disease Dementia",
abstract = "Dementia is a frequent non-motor feature of Parkinson's disease (PD). Elevated plasma homocysteine (Hcy) levels have been associated with both cognitive impairment and dementia. Increased Hcy levels have been observed in levodopa-treated patients with PD. The objective of our study was to evaluate the association between plasma Hcy levels and dementia in PD. We performed a multicenter cross-sectional study on patients with PD with (PDD) and without (PDnD) dementia and age- and sex-matched healthy controls. We compared Hcy levels in patients with PDD and PDnD and healthy controls, and we performed logistic regression analysis to search for an association between the presence of dementia and increased Hcy levels in PD. Patients with PD (121), PDD (42), and PDnD (79), and age-and sex-matched controls (154) were enrolled. Hcy levels were higher in patients with PD compared to controls (17.5 μmol (/L ± 10.2 vs. 11 ± 4.1; P <0.00001). Among patients with PD, Hcy levels were higher in the PDD group compared to the PDnD group (20.7 μmol/L ± 12.1 vs. 15.8 ± 8.5; P 5 0.002). In a multivariate logistic regression model, higher Hcy levels [Odds ratios comparing the top (>18.9 μmol/L) with the bottom tertile (",
keywords = "Dementia, Folate, Homocysteine, Parkinson's disease, Progression",
author = "Stefano Zoccolella and Claudia dell'Aquila and Giovanni Abruzzese and Angelo Antonini and Ubaldo Bonuccelli and Margherita Canesi and Silvano Cristina and Roberta Marchese and Claudio Pacchetti and Roberto Zagaglia and Giancarlo Logroscino and Giovanni Defazio and Paolo Lamberti and Paolo Livera",
year = "2009",
month = "5",
day = "15",
doi = "10.1002/mds.22511",
language = "English",
volume = "24",
pages = "1028--1033",
journal = "Movement Disorders",
issn = "0885-3185",
publisher = "John Wiley and Sons Inc.",
number = "7",

}

TY - JOUR

T1 - Hyperhomocysteinemia in levodopa-treated patients with Parkinson's disease Dementia

AU - Zoccolella, Stefano

AU - dell'Aquila, Claudia

AU - Abruzzese, Giovanni

AU - Antonini, Angelo

AU - Bonuccelli, Ubaldo

AU - Canesi, Margherita

AU - Cristina, Silvano

AU - Marchese, Roberta

AU - Pacchetti, Claudio

AU - Zagaglia, Roberto

AU - Logroscino, Giancarlo

AU - Defazio, Giovanni

AU - Lamberti, Paolo

AU - Livera, Paolo

PY - 2009/5/15

Y1 - 2009/5/15

N2 - Dementia is a frequent non-motor feature of Parkinson's disease (PD). Elevated plasma homocysteine (Hcy) levels have been associated with both cognitive impairment and dementia. Increased Hcy levels have been observed in levodopa-treated patients with PD. The objective of our study was to evaluate the association between plasma Hcy levels and dementia in PD. We performed a multicenter cross-sectional study on patients with PD with (PDD) and without (PDnD) dementia and age- and sex-matched healthy controls. We compared Hcy levels in patients with PDD and PDnD and healthy controls, and we performed logistic regression analysis to search for an association between the presence of dementia and increased Hcy levels in PD. Patients with PD (121), PDD (42), and PDnD (79), and age-and sex-matched controls (154) were enrolled. Hcy levels were higher in patients with PD compared to controls (17.5 μmol (/L ± 10.2 vs. 11 ± 4.1; P <0.00001). Among patients with PD, Hcy levels were higher in the PDD group compared to the PDnD group (20.7 μmol/L ± 12.1 vs. 15.8 ± 8.5; P 5 0.002). In a multivariate logistic regression model, higher Hcy levels [Odds ratios comparing the top (>18.9 μmol/L) with the bottom tertile (

AB - Dementia is a frequent non-motor feature of Parkinson's disease (PD). Elevated plasma homocysteine (Hcy) levels have been associated with both cognitive impairment and dementia. Increased Hcy levels have been observed in levodopa-treated patients with PD. The objective of our study was to evaluate the association between plasma Hcy levels and dementia in PD. We performed a multicenter cross-sectional study on patients with PD with (PDD) and without (PDnD) dementia and age- and sex-matched healthy controls. We compared Hcy levels in patients with PDD and PDnD and healthy controls, and we performed logistic regression analysis to search for an association between the presence of dementia and increased Hcy levels in PD. Patients with PD (121), PDD (42), and PDnD (79), and age-and sex-matched controls (154) were enrolled. Hcy levels were higher in patients with PD compared to controls (17.5 μmol (/L ± 10.2 vs. 11 ± 4.1; P <0.00001). Among patients with PD, Hcy levels were higher in the PDD group compared to the PDnD group (20.7 μmol/L ± 12.1 vs. 15.8 ± 8.5; P 5 0.002). In a multivariate logistic regression model, higher Hcy levels [Odds ratios comparing the top (>18.9 μmol/L) with the bottom tertile (

KW - Dementia

KW - Folate

KW - Homocysteine

KW - Parkinson's disease

KW - Progression

UR - http://www.scopus.com/inward/record.url?scp=67651171530&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67651171530&partnerID=8YFLogxK

U2 - 10.1002/mds.22511

DO - 10.1002/mds.22511

M3 - Article

C2 - 19353704

AN - SCOPUS:67651171530

VL - 24

SP - 1028

EP - 1033

JO - Movement Disorders

JF - Movement Disorders

SN - 0885-3185

IS - 7

ER -