Hyperhomocysteinemia in levodopa-treated patients with Parkinson's disease Dementia

Stefano Zoccolella, Claudia dell'Aquila, Giovanni Abruzzese, Angelo Antonini, Ubaldo Bonuccelli, Margherita Canesi, Silvano Cristina, Roberta Marchese, Claudio Pacchetti, Roberto Zagaglia, Giancarlo Logroscino, Giovanni Defazio, Paolo Lamberti, Paolo Livera

Research output: Contribution to journalArticlepeer-review


Dementia is a frequent non-motor feature of Parkinson's disease (PD). Elevated plasma homocysteine (Hcy) levels have been associated with both cognitive impairment and dementia. Increased Hcy levels have been observed in levodopa-treated patients with PD. The objective of our study was to evaluate the association between plasma Hcy levels and dementia in PD. We performed a multicenter cross-sectional study on patients with PD with (PDD) and without (PDnD) dementia and age- and sex-matched healthy controls. We compared Hcy levels in patients with PDD and PDnD and healthy controls, and we performed logistic regression analysis to search for an association between the presence of dementia and increased Hcy levels in PD. Patients with PD (121), PDD (42), and PDnD (79), and age-and sex-matched controls (154) were enrolled. Hcy levels were higher in patients with PD compared to controls (17.5 μmol (/L ± 10.2 vs. 11 ± 4.1; P <0.00001). Among patients with PD, Hcy levels were higher in the PDD group compared to the PDnD group (20.7 μmol/L ± 12.1 vs. 15.8 ± 8.5; P 5 0.002). In a multivariate logistic regression model, higher Hcy levels [Odds ratios comparing the top (>18.9 μmol/L) with the bottom tertile (

Original languageEnglish
Pages (from-to)1028-1033
Number of pages6
JournalMovement Disorders
Issue number7
Publication statusPublished - May 15 2009


  • Dementia
  • Folate
  • Homocysteine
  • Parkinson's disease
  • Progression

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology


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