Patients suffering from this syndrome have several immunologic dysfunctions: abnormal neutrophil chemotactic responsiveness, T lymphocyte dysfunction and depressed or absent staphylococcal hemolitic titre. Another common characteristic feature is a striking increase of blood eosinophils. Recent experimental investigations have suggested that abnormal leukocyte chemotaxis defect is due to a high level of serum histamine. The inhibitory effect of this inflammation's mediator could be related to an H2 receptor interaction. Clinical aspects of the disorder and the possible therapy are discussed, with regard to Levamisole treatment.
|Translated title of the contribution||Hyperimmunoglobulinemia E syndrome with recurrent infections|
|Number of pages||6|
|Journal||Folia Allergologica et Immunologica Clinica|
|Publication status||Published - 1979|
ASJC Scopus subject areas
- Immunology and Allergy