Iperinsulinemia e rischio cardiovascolare.

Translated title of the contribution: Hyperinsulinemia and cardiovascular risk

C. Brunelli, P. Spallarossa, R. Cordera, S. Caponnetto

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A large body of evidence has been accumulating that insulin plays a role in coronary heart disease (CHD). Hyperinsulinemia has been considered a risk factor for CHD according to prospective studies. Cross-sectional studies found an association between hyperinsulinemia and prevalence of CHD, while population studies have shown that populations at increased risk for CHD are hyperinsulinemic. Strong relations between hyperinsulinemia and atherosclerotic coronary lesions have been demonstrated by angiographic studies. It has recently been observed that also patients with microvascular angina are hyperinsulinemic. Several mechanisms have been proposed to explain the role of hyperinsulinemia in the development of atherothrombosis. Hyperinsulinemia is the consequence of insulin resistance, a defect in insulin-mediated glucose uptake. Experimental evidence suggests that insulin has actions that may promote atherosclerosis, which clinical studies suggest the existence of a metabolic syndrome characterized by the presence of major coronary risk factors in which insulin resistance is the common link.

Original languageItalian
Pages (from-to)163-168
Number of pages6
JournalCardiologia
Volume39
Issue number12 Suppl 1
Publication statusPublished - Dec 1994

Fingerprint

Hyperinsulinism
Coronary Disease
Insulin
Insulin Resistance
Microvascular Angina
Atherosclerosis
Cross-Sectional Studies
Prospective Studies
Glucose
Population

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Brunelli, C., Spallarossa, P., Cordera, R., & Caponnetto, S. (1994). Iperinsulinemia e rischio cardiovascolare. Cardiologia, 39(12 Suppl 1), 163-168.

Iperinsulinemia e rischio cardiovascolare. / Brunelli, C.; Spallarossa, P.; Cordera, R.; Caponnetto, S.

In: Cardiologia, Vol. 39, No. 12 Suppl 1, 12.1994, p. 163-168.

Research output: Contribution to journalArticle

Brunelli, C, Spallarossa, P, Cordera, R & Caponnetto, S 1994, 'Iperinsulinemia e rischio cardiovascolare.', Cardiologia, vol. 39, no. 12 Suppl 1, pp. 163-168.
Brunelli C, Spallarossa P, Cordera R, Caponnetto S. Iperinsulinemia e rischio cardiovascolare. Cardiologia. 1994 Dec;39(12 Suppl 1):163-168.
Brunelli, C. ; Spallarossa, P. ; Cordera, R. ; Caponnetto, S. / Iperinsulinemia e rischio cardiovascolare. In: Cardiologia. 1994 ; Vol. 39, No. 12 Suppl 1. pp. 163-168.
@article{95eda79bf70b4b1584c558c885cea8f5,
title = "Iperinsulinemia e rischio cardiovascolare.",
abstract = "A large body of evidence has been accumulating that insulin plays a role in coronary heart disease (CHD). Hyperinsulinemia has been considered a risk factor for CHD according to prospective studies. Cross-sectional studies found an association between hyperinsulinemia and prevalence of CHD, while population studies have shown that populations at increased risk for CHD are hyperinsulinemic. Strong relations between hyperinsulinemia and atherosclerotic coronary lesions have been demonstrated by angiographic studies. It has recently been observed that also patients with microvascular angina are hyperinsulinemic. Several mechanisms have been proposed to explain the role of hyperinsulinemia in the development of atherothrombosis. Hyperinsulinemia is the consequence of insulin resistance, a defect in insulin-mediated glucose uptake. Experimental evidence suggests that insulin has actions that may promote atherosclerosis, which clinical studies suggest the existence of a metabolic syndrome characterized by the presence of major coronary risk factors in which insulin resistance is the common link.",
author = "C. Brunelli and P. Spallarossa and R. Cordera and S. Caponnetto",
year = "1994",
month = "12",
language = "Italian",
volume = "39",
pages = "163--168",
journal = "Cardiologia (Rome, Italy)",
issn = "0393-1978",
publisher = "Societa Italiana di Cardiologia",
number = "12 Suppl 1",

}

TY - JOUR

T1 - Iperinsulinemia e rischio cardiovascolare.

AU - Brunelli, C.

AU - Spallarossa, P.

AU - Cordera, R.

AU - Caponnetto, S.

PY - 1994/12

Y1 - 1994/12

N2 - A large body of evidence has been accumulating that insulin plays a role in coronary heart disease (CHD). Hyperinsulinemia has been considered a risk factor for CHD according to prospective studies. Cross-sectional studies found an association between hyperinsulinemia and prevalence of CHD, while population studies have shown that populations at increased risk for CHD are hyperinsulinemic. Strong relations between hyperinsulinemia and atherosclerotic coronary lesions have been demonstrated by angiographic studies. It has recently been observed that also patients with microvascular angina are hyperinsulinemic. Several mechanisms have been proposed to explain the role of hyperinsulinemia in the development of atherothrombosis. Hyperinsulinemia is the consequence of insulin resistance, a defect in insulin-mediated glucose uptake. Experimental evidence suggests that insulin has actions that may promote atherosclerosis, which clinical studies suggest the existence of a metabolic syndrome characterized by the presence of major coronary risk factors in which insulin resistance is the common link.

AB - A large body of evidence has been accumulating that insulin plays a role in coronary heart disease (CHD). Hyperinsulinemia has been considered a risk factor for CHD according to prospective studies. Cross-sectional studies found an association between hyperinsulinemia and prevalence of CHD, while population studies have shown that populations at increased risk for CHD are hyperinsulinemic. Strong relations between hyperinsulinemia and atherosclerotic coronary lesions have been demonstrated by angiographic studies. It has recently been observed that also patients with microvascular angina are hyperinsulinemic. Several mechanisms have been proposed to explain the role of hyperinsulinemia in the development of atherothrombosis. Hyperinsulinemia is the consequence of insulin resistance, a defect in insulin-mediated glucose uptake. Experimental evidence suggests that insulin has actions that may promote atherosclerosis, which clinical studies suggest the existence of a metabolic syndrome characterized by the presence of major coronary risk factors in which insulin resistance is the common link.

UR - http://www.scopus.com/inward/record.url?scp=0028700462&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028700462&partnerID=8YFLogxK

M3 - Articolo

VL - 39

SP - 163

EP - 168

JO - Cardiologia (Rome, Italy)

JF - Cardiologia (Rome, Italy)

SN - 0393-1978

IS - 12 Suppl 1

ER -