Hyperinsulinemia and insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. The GISIR database

Enzo Bonora; Brunella Capaldo; Paolo Cavallo Perin; Stefano del Prato; Giancarlo de Mattia; Lucia Frittitta; Simona Frontoni; Frida Leonetti; Livio Luzi; Giulio Marchesini; Maria Adelaide Marini; Andrea Natali; Giuseppe Paolisso; Pier Marco Piatti; Arturo Pujia; Anna Solini; Roberto Vettor; Riccardo C. Bonadonna; Ele Ferrannini; Roberto Baratta; Salvatore Graci; Daniela Bracaglia; Lucilla Monti; Emanuela Setola; Tiziana Montalcini; Giorgio Sesti; Saula Vigili de Kreutzenberg

doi:10.1016/j.numecd.2007.05.002

Hyperinsulinemia and insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. The GISIR database

Enzo Bonora, Brunella Capaldo, Paolo Cavallo Perin, Stefano del Prato, Giancarlo de Mattia, Lucia Frittitta, Simona Frontoni, Frida Leonetti, Livio Luzi, Giulio Marchesini, Maria Adelaide Marini, Andrea Natali, Giuseppe Paolisso, Pier Marco Piatti, Arturo Pujia, Anna Solini, Roberto Vettor, Riccardo C. Bonadonna, Ele Ferrannini, Roberto BarattaSalvatore Graci, Daniela Bracaglia, Lucilla Monti, Emanuela Setola, Tiziana Montalcini, Giorgio Sesti, Saula Vigili de Kreutzenberg

Research output: Contribution to journal › Article › peer-review

Abstract

Background and aims: We evaluated whether hyperinsulinemia and/or insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. Methods and results: A database of non-diabetic Italian subjects has recently been set up using data from hyperinsulinemic euglycemic clamp studies carried out using the standard technique (40 mU per min per square meter of body surface area). In this database we evaluated the relationships between fasting plasma insulin (FPI), glucose metabolized during clamp (M) and plasma levels of triglycerides (TG), high density lipoprotein cholesterol (HDL-C), uric acid (UA) as well as blood pressure (BP) in non-diabetic subjects with fasting plasma glucose

Original language	English
Pages (from-to)	624-631
Number of pages	8
Journal	Nutrition, Metabolism and Cardiovascular Diseases
Volume	18
Issue number	9
DOIs	https://doi.org/10.1016/j.numecd.2007.05.002
Publication status	Published - Nov 2008

Keywords

Blood pressure
HDL-cholesterol
Insulin
Insulin resistance
Triglycerides
Uric acid

ASJC Scopus subject areas

Medicine (miscellaneous)
Nutrition and Dietetics
Endocrinology, Diabetes and Metabolism
Cardiology and Cardiovascular Medicine

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Bonora, E., Capaldo, B., Perin, P. C., del Prato, S., de Mattia, G., Frittitta, L., Frontoni, S., Leonetti, F., Luzi, L., Marchesini, G., Marini, M. A., Natali, A., Paolisso, G., Piatti, P. M., Pujia, A., Solini, A., Vettor, R., Bonadonna, R. C., Ferrannini, E., ... de Kreutzenberg, S. V. (2008). Hyperinsulinemia and insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. The GISIR database. Nutrition, Metabolism and Cardiovascular Diseases, 18(9), 624-631. https://doi.org/10.1016/j.numecd.2007.05.002

Hyperinsulinemia and insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. The GISIR database. / Bonora, Enzo; Capaldo, Brunella; Perin, Paolo Cavallo; del Prato, Stefano; de Mattia, Giancarlo; Frittitta, Lucia; Frontoni, Simona; Leonetti, Frida; Luzi, Livio; Marchesini, Giulio; Marini, Maria Adelaide; Natali, Andrea; Paolisso, Giuseppe; Piatti, Pier Marco; Pujia, Arturo; Solini, Anna; Vettor, Roberto; Bonadonna, Riccardo C.; Ferrannini, Ele; Baratta, Roberto; Graci, Salvatore; Bracaglia, Daniela; Monti, Lucilla; Setola, Emanuela; Montalcini, Tiziana; Sesti, Giorgio; de Kreutzenberg, Saula Vigili.

In: Nutrition, Metabolism and Cardiovascular Diseases, Vol. 18, No. 9, 11.2008, p. 624-631.

Research output: Contribution to journal › Article › peer-review

Bonora, E, Capaldo, B, Perin, PC, del Prato, S, de Mattia, G, Frittitta, L, Frontoni, S, Leonetti, F, Luzi, L, Marchesini, G, Marini, MA, Natali, A, Paolisso, G, Piatti, PM, Pujia, A, Solini, A, Vettor, R, Bonadonna, RC, Ferrannini, E, Baratta, R, Graci, S, Bracaglia, D, Monti, L, Setola, E, Montalcini, T, Sesti, G & de Kreutzenberg, SV 2008, 'Hyperinsulinemia and insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. The GISIR database', Nutrition, Metabolism and Cardiovascular Diseases, vol. 18, no. 9, pp. 624-631. https://doi.org/10.1016/j.numecd.2007.05.002

Bonora, Enzo ; Capaldo, Brunella ; Perin, Paolo Cavallo ; del Prato, Stefano ; de Mattia, Giancarlo ; Frittitta, Lucia ; Frontoni, Simona ; Leonetti, Frida ; Luzi, Livio ; Marchesini, Giulio ; Marini, Maria Adelaide ; Natali, Andrea ; Paolisso, Giuseppe ; Piatti, Pier Marco ; Pujia, Arturo ; Solini, Anna ; Vettor, Roberto ; Bonadonna, Riccardo C. ; Ferrannini, Ele ; Baratta, Roberto ; Graci, Salvatore ; Bracaglia, Daniela ; Monti, Lucilla ; Setola, Emanuela ; Montalcini, Tiziana ; Sesti, Giorgio ; de Kreutzenberg, Saula Vigili. / Hyperinsulinemia and insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. The GISIR database. In: Nutrition, Metabolism and Cardiovascular Diseases. 2008 ; Vol. 18, No. 9. pp. 624-631.

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AU - Graci, Salvatore

AU - Bracaglia, Daniela

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