Hyperinsulinemia and insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. The GISIR database

Enzo Bonora; Brunella Capaldo; Paolo Cavallo Perin; Stefano del Prato; Giancarlo de Mattia; Lucia Frittitta; Simona Frontoni; Frida Leonetti; Livio Luzi; Giulio Marchesini; Maria Adelaide Marini; Andrea Natali; Giuseppe Paolisso; Pier Marco Piatti; Arturo Pujia; Anna Solini; Roberto Vettor; Riccardo C. Bonadonna; Ele Ferrannini; Roberto Baratta; Salvatore Graci; Daniela Bracaglia; Lucilla Monti; Emanuela Setola; Tiziana Montalcini; Giorgio Sesti; Saula Vigili de Kreutzenberg

doi:10.1016/j.numecd.2007.05.002

Hyperinsulinemia and insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. The GISIR database

Enzo Bonora, Brunella Capaldo, Paolo Cavallo Perin, Stefano del Prato, Giancarlo de Mattia, Lucia Frittitta, Simona Frontoni, Frida Leonetti, Livio Luzi, Giulio Marchesini, Maria Adelaide Marini, Andrea Natali, Giuseppe Paolisso, Pier Marco Piatti, Arturo Pujia, Anna Solini, Roberto Vettor, Riccardo C. Bonadonna, Ele Ferrannini, Roberto BarattaSalvatore Graci, Daniela Bracaglia, Lucilla Monti, Emanuela Setola, Tiziana Montalcini, Giorgio Sesti, Saula Vigili de Kreutzenberg

Research output: Contribution to journal › Article › peer-review

Abstract

Background and aims: We evaluated whether hyperinsulinemia and/or insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. Methods and results: A database of non-diabetic Italian subjects has recently been set up using data from hyperinsulinemic euglycemic clamp studies carried out using the standard technique (40 mU per min per square meter of body surface area). In this database we evaluated the relationships between fasting plasma insulin (FPI), glucose metabolized during clamp (M) and plasma levels of triglycerides (TG), high density lipoprotein cholesterol (HDL-C), uric acid (UA) as well as blood pressure (BP) in non-diabetic subjects with fasting plasma glucose

Original language	English
Pages (from-to)	624-631
Number of pages	8
Journal	Nutrition, Metabolism and Cardiovascular Diseases
Volume	18
Issue number	9
DOIs	https://doi.org/10.1016/j.numecd.2007.05.002
Publication status	Published - Nov 2008

Keywords

Blood pressure
HDL-cholesterol
Insulin
Insulin resistance
Triglycerides
Uric acid

ASJC Scopus subject areas

Medicine (miscellaneous)
Nutrition and Dietetics
Endocrinology, Diabetes and Metabolism
Cardiology and Cardiovascular Medicine

Access to Document

10.1016/j.numecd.2007.05.002

Cite this

Bonora, E., Capaldo, B., Perin, P. C., del Prato, S., de Mattia, G., Frittitta, L., Frontoni, S., Leonetti, F., Luzi, L., Marchesini, G., Marini, M. A., Natali, A., Paolisso, G., Piatti, P. M., Pujia, A., Solini, A., Vettor, R., Bonadonna, R. C., Ferrannini, E., ... de Kreutzenberg, S. V. (2008). Hyperinsulinemia and insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. The GISIR database. Nutrition, Metabolism and Cardiovascular Diseases, 18(9), 624-631. https://doi.org/10.1016/j.numecd.2007.05.002

Hyperinsulinemia and insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. The GISIR database. / Bonora, Enzo; Capaldo, Brunella; Perin, Paolo Cavallo; del Prato, Stefano; de Mattia, Giancarlo; Frittitta, Lucia; Frontoni, Simona; Leonetti, Frida; Luzi, Livio; Marchesini, Giulio; Marini, Maria Adelaide; Natali, Andrea; Paolisso, Giuseppe; Piatti, Pier Marco; Pujia, Arturo; Solini, Anna; Vettor, Roberto; Bonadonna, Riccardo C.; Ferrannini, Ele; Baratta, Roberto; Graci, Salvatore; Bracaglia, Daniela; Monti, Lucilla; Setola, Emanuela; Montalcini, Tiziana; Sesti, Giorgio; de Kreutzenberg, Saula Vigili.

In: Nutrition, Metabolism and Cardiovascular Diseases, Vol. 18, No. 9, 11.2008, p. 624-631.

Research output: Contribution to journal › Article › peer-review

Bonora, E, Capaldo, B, Perin, PC, del Prato, S, de Mattia, G, Frittitta, L, Frontoni, S, Leonetti, F, Luzi, L, Marchesini, G, Marini, MA, Natali, A, Paolisso, G, Piatti, PM, Pujia, A, Solini, A, Vettor, R, Bonadonna, RC, Ferrannini, E, Baratta, R, Graci, S, Bracaglia, D, Monti, L, Setola, E, Montalcini, T, Sesti, G & de Kreutzenberg, SV 2008, 'Hyperinsulinemia and insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. The GISIR database', Nutrition, Metabolism and Cardiovascular Diseases, vol. 18, no. 9, pp. 624-631. https://doi.org/10.1016/j.numecd.2007.05.002

Bonora, Enzo ; Capaldo, Brunella ; Perin, Paolo Cavallo ; del Prato, Stefano ; de Mattia, Giancarlo ; Frittitta, Lucia ; Frontoni, Simona ; Leonetti, Frida ; Luzi, Livio ; Marchesini, Giulio ; Marini, Maria Adelaide ; Natali, Andrea ; Paolisso, Giuseppe ; Piatti, Pier Marco ; Pujia, Arturo ; Solini, Anna ; Vettor, Roberto ; Bonadonna, Riccardo C. ; Ferrannini, Ele ; Baratta, Roberto ; Graci, Salvatore ; Bracaglia, Daniela ; Monti, Lucilla ; Setola, Emanuela ; Montalcini, Tiziana ; Sesti, Giorgio ; de Kreutzenberg, Saula Vigili. / Hyperinsulinemia and insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. The GISIR database. In: Nutrition, Metabolism and Cardiovascular Diseases. 2008 ; Vol. 18, No. 9. pp. 624-631.

@article{7f0319a7a57642b7993123300675dd91,

title = "Hyperinsulinemia and insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. The GISIR database",

abstract = "Background and aims: We evaluated whether hyperinsulinemia and/or insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. Methods and results: A database of non-diabetic Italian subjects has recently been set up using data from hyperinsulinemic euglycemic clamp studies carried out using the standard technique (40 mU per min per square meter of body surface area). In this database we evaluated the relationships between fasting plasma insulin (FPI), glucose metabolized during clamp (M) and plasma levels of triglycerides (TG), high density lipoprotein cholesterol (HDL-C), uric acid (UA) as well as blood pressure (BP) in non-diabetic subjects with fasting plasma glucose ",

keywords = "Blood pressure, HDL-cholesterol, Insulin, Insulin resistance, Triglycerides, Uric acid",

author = "Enzo Bonora and Brunella Capaldo and Perin, {Paolo Cavallo} and {del Prato}, Stefano and {de Mattia}, Giancarlo and Lucia Frittitta and Simona Frontoni and Frida Leonetti and Livio Luzi and Giulio Marchesini and Marini, {Maria Adelaide} and Andrea Natali and Giuseppe Paolisso and Piatti, {Pier Marco} and Arturo Pujia and Anna Solini and Roberto Vettor and Bonadonna, {Riccardo C.} and Ele Ferrannini and Roberto Baratta and Salvatore Graci and Daniela Bracaglia and Lucilla Monti and Emanuela Setola and Tiziana Montalcini and Giorgio Sesti and {de Kreutzenberg}, {Saula Vigili}",

year = "2008",

month = nov,

doi = "10.1016/j.numecd.2007.05.002",

language = "English",

volume = "18",

pages = "624--631",

journal = "Nutrition, Metabolism and Cardiovascular Diseases",

issn = "0939-4753",

publisher = "Elsevier B.V.",

number = "9",

}

TY - JOUR

T1 - Hyperinsulinemia and insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. The GISIR database

AU - Bonora, Enzo

AU - Capaldo, Brunella

AU - Perin, Paolo Cavallo

AU - del Prato, Stefano

AU - de Mattia, Giancarlo

AU - Frittitta, Lucia

AU - Frontoni, Simona

AU - Leonetti, Frida

AU - Luzi, Livio

AU - Marchesini, Giulio

AU - Marini, Maria Adelaide

AU - Natali, Andrea

AU - Paolisso, Giuseppe

AU - Piatti, Pier Marco

AU - Pujia, Arturo

AU - Solini, Anna

AU - Vettor, Roberto

AU - Bonadonna, Riccardo C.

AU - Ferrannini, Ele

AU - Baratta, Roberto

AU - Graci, Salvatore

AU - Bracaglia, Daniela

AU - Monti, Lucilla

AU - Setola, Emanuela

AU - Montalcini, Tiziana

AU - Sesti, Giorgio

AU - de Kreutzenberg, Saula Vigili

PY - 2008/11

Y1 - 2008/11

N2 - Background and aims: We evaluated whether hyperinsulinemia and/or insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. Methods and results: A database of non-diabetic Italian subjects has recently been set up using data from hyperinsulinemic euglycemic clamp studies carried out using the standard technique (40 mU per min per square meter of body surface area). In this database we evaluated the relationships between fasting plasma insulin (FPI), glucose metabolized during clamp (M) and plasma levels of triglycerides (TG), high density lipoprotein cholesterol (HDL-C), uric acid (UA) as well as blood pressure (BP) in non-diabetic subjects with fasting plasma glucose

AB - Background and aims: We evaluated whether hyperinsulinemia and/or insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. Methods and results: A database of non-diabetic Italian subjects has recently been set up using data from hyperinsulinemic euglycemic clamp studies carried out using the standard technique (40 mU per min per square meter of body surface area). In this database we evaluated the relationships between fasting plasma insulin (FPI), glucose metabolized during clamp (M) and plasma levels of triglycerides (TG), high density lipoprotein cholesterol (HDL-C), uric acid (UA) as well as blood pressure (BP) in non-diabetic subjects with fasting plasma glucose

KW - Blood pressure

KW - HDL-cholesterol

KW - Insulin

KW - Insulin resistance

KW - Triglycerides

KW - Uric acid

UR - http://www.scopus.com/inward/record.url?scp=54049089061&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=54049089061&partnerID=8YFLogxK

U2 - 10.1016/j.numecd.2007.05.002

DO - 10.1016/j.numecd.2007.05.002

M3 - Article

C2 - 18060751

AN - SCOPUS:54049089061

VL - 18

SP - 624

EP - 631

JO - Nutrition, Metabolism and Cardiovascular Diseases

JF - Nutrition, Metabolism and Cardiovascular Diseases

SN - 0939-4753

IS - 9

ER -

Hyperinsulinemia and insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. The GISIR database

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this