Hyperinsulinemia and insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. The GISIR database

Enzo Bonora, Brunella Capaldo, Paolo Cavallo Perin, Stefano del Prato, Giancarlo de Mattia, Lucia Frittitta, Simona Frontoni, Frida Leonetti, Livio Luzi, Giulio Marchesini, Maria Adelaide Marini, Andrea Natali, Giuseppe Paolisso, Pier Marco Piatti, Arturo Pujia, Anna Solini, Roberto Vettor, Riccardo C. Bonadonna, Ele Ferrannini, Roberto BarattaSalvatore Graci, Daniela Bracaglia, Lucilla Monti, Emanuela Setola, Tiziana Montalcini, Giorgio Sesti, Saula Vigili de Kreutzenberg

Research output: Contribution to journalArticlepeer-review

Abstract

Background and aims: We evaluated whether hyperinsulinemia and/or insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. Methods and results: A database of non-diabetic Italian subjects has recently been set up using data from hyperinsulinemic euglycemic clamp studies carried out using the standard technique (40 mU per min per square meter of body surface area). In this database we evaluated the relationships between fasting plasma insulin (FPI), glucose metabolized during clamp (M) and plasma levels of triglycerides (TG), high density lipoprotein cholesterol (HDL-C), uric acid (UA) as well as blood pressure (BP) in non-diabetic subjects with fasting plasma glucose

Original languageEnglish
Pages (from-to)624-631
Number of pages8
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume18
Issue number9
DOIs
Publication statusPublished - Nov 2008

Keywords

  • Blood pressure
  • HDL-cholesterol
  • Insulin
  • Insulin resistance
  • Triglycerides
  • Uric acid

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine

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