Hyperinsulinemia predicts hepatic fat content in healthy individuals with normal transaminase concentrations

Diego Ardigò, Filippo Numeroso, Silvia Valtueña, Laura Franzini, Pier Marco Piatti, Lucilla Monti, Roberto Delsignore, Gerald M. Reaven, Ivana Zavaroni

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Although the prevalence of insulin resistance (IR) and compensatory hyperinsulinemia (CH) is increased in patients with nonalcoholic fatty liver disease, the role of IR/CH in regulation of hepatic fat content in healthy volunteers with normal concentrations of alanine transaminase (ALT) has not been defined. To address this issue, hepatic fat content was quantified by ultrasound in 69 (30 men, 39 women) healthy individuals, without known risk factors for liver disease and with plasma ALT concentrations of less than 30 U/L. Experimental variables quantified included body mass index, waist circumference, systolic and diastolic blood pressures, and fasting plasma glucose, fasting plasma insulin (FPI), and lipid concentrations. Subjects were classified as having no (55%), mild (27%), or moderate to severe (18%) hepatic steatosis on the basis of the ultrasound results. Statistically significant (P <.05-.001) correlations (Spearman ρ values) existed between liver fat content and ALT (0.26), body mass index (0.52), waist circumference (0.50), systolic blood pressure (0.28), diastolic blood pressure (0.27), fasting plasma glucose (0.47), FPI (0.56), triglycerides (0.30), and high-density lipoprotein cholesterol (-0.35). Multivariate general discriminant analysis and multiple linear regression analysis indicated that FPI was the only independent predictor (P <.001) of both liver fat content and ALT concentrations. Fasting plasma insulin (a surrogate estimate of IR/CH) predicts hepatic fat content and ALT in healthy volunteers with normal transaminase concentrations, independently of the other anthropometric and metabolic variables measured.

Original languageEnglish
Pages (from-to)1566-1570
Number of pages5
JournalMetabolism
Volume54
Issue number12
DOIs
Publication statusPublished - Dec 2005

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Hyperinsulinism
Transaminases
Fats
Fasting
Alanine Transaminase
Blood Pressure
Liver
Insulin
Insulin Resistance
Waist Circumference
Healthy Volunteers
Body Mass Index
Glucose
Discriminant Analysis
HDL Cholesterol
Liver Diseases
Linear Models
Triglycerides
Regression Analysis
Lipids

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Hyperinsulinemia predicts hepatic fat content in healthy individuals with normal transaminase concentrations. / Ardigò, Diego; Numeroso, Filippo; Valtueña, Silvia; Franzini, Laura; Piatti, Pier Marco; Monti, Lucilla; Delsignore, Roberto; Reaven, Gerald M.; Zavaroni, Ivana.

In: Metabolism, Vol. 54, No. 12, 12.2005, p. 1566-1570.

Research output: Contribution to journalArticle

Ardigò, D, Numeroso, F, Valtueña, S, Franzini, L, Piatti, PM, Monti, L, Delsignore, R, Reaven, GM & Zavaroni, I 2005, 'Hyperinsulinemia predicts hepatic fat content in healthy individuals with normal transaminase concentrations', Metabolism, vol. 54, no. 12, pp. 1566-1570. https://doi.org/10.1016/j.metabol.2005.05.027
Ardigò, Diego ; Numeroso, Filippo ; Valtueña, Silvia ; Franzini, Laura ; Piatti, Pier Marco ; Monti, Lucilla ; Delsignore, Roberto ; Reaven, Gerald M. ; Zavaroni, Ivana. / Hyperinsulinemia predicts hepatic fat content in healthy individuals with normal transaminase concentrations. In: Metabolism. 2005 ; Vol. 54, No. 12. pp. 1566-1570.
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