Iperintensita dei nuclei della base nelle sequenze RM T1-W in un caso di shunt porto-sistemico senza insufficienza epatica

Translated title of the contribution: Hyperintense basal ganglia on T1-weighted MR sequences in a case of portal-systemic shunt without liver failure

L. Gozzoli, L. Ambrogio, M. Grasso, L. Ghezzo, G. P. Magro, G. B. Bradac, M. Bergui, C. Ferro

Research output: Contribution to journalArticle

Abstract

Hyperintense basal ganglia in T1-weighted MR sequences is a common finding in patients with advanced liver cirrhosis. This signal alteration has been correlated with the severity of liver failure and the presence of portal-systemic shunts, but its origin and clinical significance remain unsettled. On the one hand, hyperintense globus pallidus is closely linked with acquired hepatocerebral degeneration. On the other, MR changes may reflect a subclinical, possibly reversible, encephalopathy prior to the onset of neurological symptoms. We describe a young patient who underwent MR investigation to establish the cause of an impairment of the hypothalamic-hypophyseal axis. An increase in signal intensity was encountered in T1-weighted sequences in the globus pallidus of the subthalamic and adenohypophyseal regions. The most striking feature of our case was the normal values of liver function tests. The patient had undergone surgery for splenorenal anastomosis at the age of 16 years for thrombosis of the hepatic veins caused by an error in cannulating the umbilical vein in the first 48 hours of life. We discuss the possible causes of the MR signal changes in the basal ganglia, emphasizing the importance of opening portal-systemic shunts to release substances like manganese which tend to accumulate in these areas and shorten T1-weighted imaging times.

Original languageItalian
Pages (from-to)493-500
Number of pages8
JournalRivista di Neuroradiologia
Volume9
Issue number4
Publication statusPublished - 1996

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Liver Failure
Basal Ganglia
Globus Pallidus
Budd-Chiari Syndrome
Umbilical Veins
Hepatolenticular Degeneration
Liver Function Tests
Brain Diseases
Manganese
Liver Cirrhosis
Reference Values

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Radiological and Ultrasound Technology

Cite this

Gozzoli, L., Ambrogio, L., Grasso, M., Ghezzo, L., Magro, G. P., Bradac, G. B., ... Ferro, C. (1996). Iperintensita dei nuclei della base nelle sequenze RM T1-W in un caso di shunt porto-sistemico senza insufficienza epatica. Rivista di Neuroradiologia, 9(4), 493-500.

Iperintensita dei nuclei della base nelle sequenze RM T1-W in un caso di shunt porto-sistemico senza insufficienza epatica. / Gozzoli, L.; Ambrogio, L.; Grasso, M.; Ghezzo, L.; Magro, G. P.; Bradac, G. B.; Bergui, M.; Ferro, C.

In: Rivista di Neuroradiologia, Vol. 9, No. 4, 1996, p. 493-500.

Research output: Contribution to journalArticle

Gozzoli, L, Ambrogio, L, Grasso, M, Ghezzo, L, Magro, GP, Bradac, GB, Bergui, M & Ferro, C 1996, 'Iperintensita dei nuclei della base nelle sequenze RM T1-W in un caso di shunt porto-sistemico senza insufficienza epatica', Rivista di Neuroradiologia, vol. 9, no. 4, pp. 493-500.
Gozzoli, L. ; Ambrogio, L. ; Grasso, M. ; Ghezzo, L. ; Magro, G. P. ; Bradac, G. B. ; Bergui, M. ; Ferro, C. / Iperintensita dei nuclei della base nelle sequenze RM T1-W in un caso di shunt porto-sistemico senza insufficienza epatica. In: Rivista di Neuroradiologia. 1996 ; Vol. 9, No. 4. pp. 493-500.
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