The definition of hyperkeratotic skin diseases is referred to inflammatory skin disorders, clinically characterized by scaling and erythema, and microscopically showing variable thickening of the stratum corneum and epidermis (acanthosis) associated with variable degree of inflammation involving epidermis and dermis. Hyperkeratosis can be orthokeratotic as well as with parakeratosis; acanthosis can be regular, generally associated with papillomatosis (i.e. in psoriasis) or irregularly distributed and with different degree of epidermal thickening. Papillomatosis, histopathologically, is seen as elongation of the rete ridges, dilated dermal papillae and normal epidermal structures. The main hyperkeratotic skin diseases, in terms of frequency and social impact, are plaque psoriasis and seborrheic dermatitis.
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