Hyperkinetic disorders and loss of synaptic downscaling

Paolo Calabresi, Antonio Pisani, John Rothwell, Veronica Ghiglieri, Josè A. Obeso, Barbara Picconi

Research output: Contribution to journalReview articlepeer-review


Recent clinical and preclinical studies have shown that hyperkinetic disorders such as Huntington's disease, dystonia and l-DOPA-induced dyskinesia in Parkinson's disease are all characterized by loss of the ability to reverse synaptic plasticity and an associated increase in the excitability of excitatory neuronal inputs to a range of cortical and subcortical brain areas. Moreover, these changes have been detected in humans with hyperkinetic disorders either via direct recordings from implanted deep brain electrodes or noninvasively using transcranial magnetic stimulation. Here we discuss the mechanisms underlying the loss of bidirectional plasticity and the possibility that future interventions could be devised to reverse these changes in patients with hyperkinetic movement disorders.

Original languageEnglish
Pages (from-to)868-875
Number of pages8
JournalNature Neuroscience
Issue number7
Publication statusPublished - Jul 1 2016

ASJC Scopus subject areas

  • Neuroscience(all)


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