Hyperlipidaemia and atherosclerotic cerebrovascular disease

A. Postiglione, C. Napoli

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Controversies exist concerning the role of hypercholesterolaemia as a risk factor for nonhaemorrhagic stroke because intracranial arteries seem to be more resistant than coronary arteries to cholesterol-induced endothelial damage. Only very high levels of serum cholesterol seem to be a significant risk factor. It is possible that coronary heart disease may occur earlier in life than cerebrovascular atherosclerosis, and it could then become the cause of stroke. In our view, the causal relationship between very low levels of serum cholesterol and haemorrhagic stroke is unlikely, and cholesterol-lowering treatment appears to be safe. New studies should consider the particular metabolic aspects of intracranial arteries and the independent role of lipoprotein (a), apolipoprotein E phenotypes and other molecular and genetic mechanisms involved in atherosclerotic cerebrovascular disease.

Original languageEnglish
Pages (from-to)236-242
Number of pages7
JournalCurrent Opinion in Lipidology
Volume6
Issue number4
Publication statusPublished - 1995

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Cerebrovascular Disorders
Hyperlipidemias
Stroke
Cholesterol
Hypercholesterolemia
Arteries
Lipoprotein(a)
Apolipoproteins E
Serum
Coronary Disease
Molecular Biology
Atherosclerosis
Coronary Vessels
Phenotype

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Hyperlipidaemia and atherosclerotic cerebrovascular disease. / Postiglione, A.; Napoli, C.

In: Current Opinion in Lipidology, Vol. 6, No. 4, 1995, p. 236-242.

Research output: Contribution to journalArticle

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