Hyperlipidaemic state and cardiovascular risk in primary biliary cirrhosis

M. Longo, A. Crosignani, P. M. Battezzati, C. Squarcia Giussani, P. Invernizzi, M. Zuin, Mauro Podda

Research output: Contribution to journalArticlepeer-review


Background: Primary biliary cirrhosis (PBC), a chronic cholestatic liver disease, is frequently associated with severe hypercholesterolaemia but the clinical significance of this finding is unclear. Aims: To characterise changes in serum lipid profile over time and to assess the risk of cardiovascular disease in PBC. Subjects and methods: We studied a cohort of 400 PBC patients for 6.2 years (range 4 months to 24 years) by serial determinations of serum lipid levels and registration of all cardiovascular events. Subjects included in an Italian prospective population based study served as controls. Results: At presentation, 76% of patients had serum cholesterol levels >5.2 mmol/l. Hyperbilirubinaemic patients had higher total cholesterol and lower high density lipoprotein (HDL) cholesterol levels (p

Original languageEnglish
Pages (from-to)265-269
Number of pages5
Issue number2
Publication statusPublished - 2002

ASJC Scopus subject areas

  • Gastroenterology


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