Hyperlipidaemic state and cardiovascular risk in primary biliary cirrhosis

M. Longo; A. Crosignani; P. M. Battezzati; C. Squarcia Giussani; P. Invernizzi; M. Zuin; Mauro Podda

doi:10.1136/gut.51.2.265

Hyperlipidaemic state and cardiovascular risk in primary biliary cirrhosis

M. Longo, A. Crosignani, P. M. Battezzati, C. Squarcia Giussani, P. Invernizzi, M. Zuin, Mauro Podda

Istituto Clinico Humanitas

Research output: Contribution to journal › Article

Abstract

Background: Primary biliary cirrhosis (PBC), a chronic cholestatic liver disease, is frequently associated with severe hypercholesterolaemia but the clinical significance of this finding is unclear. Aims: To characterise changes in serum lipid profile over time and to assess the risk of cardiovascular disease in PBC. Subjects and methods: We studied a cohort of 400 PBC patients for 6.2 years (range 4 months to 24 years) by serial determinations of serum lipid levels and registration of all cardiovascular events. Subjects included in an Italian prospective population based study served as controls. Results: At presentation, 76% of patients had serum cholesterol levels >5.2 mmol/l. Hyperbilirubinaemic patients had higher total cholesterol and lower high density lipoprotein (HDL) cholesterol levels (p

Original language	English
Pages (from-to)	265-269
Number of pages	5
Journal	Gut
Volume	51
Issue number	2
DOIs	https://doi.org/10.1136/gut.51.2.265
Publication status	Published - 2002

ASJC Scopus subject areas

Gastroenterology

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Longo, M., Crosignani, A., Battezzati, P. M., Squarcia Giussani, C., Invernizzi, P., Zuin, M., & Podda, M. (2002). Hyperlipidaemic state and cardiovascular risk in primary biliary cirrhosis. Gut, 51(2), 265-269. https://doi.org/10.1136/gut.51.2.265

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T1 - Hyperlipidaemic state and cardiovascular risk in primary biliary cirrhosis

AU - Longo, M.

AU - Crosignani, A.

AU - Battezzati, P. M.

AU - Squarcia Giussani, C.

AU - Invernizzi, P.

AU - Zuin, M.

AU - Podda, Mauro

PY - 2002

Y1 - 2002

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