Iperparatiroidismo primitivo e pancreatite acuta. Una rara associazione clinica

Translated title of the contribution: Hyperparathyroidism and acute pancreatitis. A rare clinical association

M. Boneschi, M. Erba, L. Beretta, S. Miani, E. M. Bortolani

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Hyperparathyroidism and hypercalcaemia are considered to be a rare cause of acute pancreatitis. The relationship between hyperparathyroidism and pancreatic inflammatory disease remains controversial, but it may be related to the translation from inactive to active trypsinogen by hypercalcaemia. Surgical correction of parathyroid disease and normalization of serum calcium levels may ameliorate the acute pancreatitis. Also the mechanism of pathologic zymogen activation during acute pancreatitis remain unknown; probably the pancreatic 'autodigestion' is the result of anomalous intracellular transport of secretory proteins activated by lysosomal hydrolases. A case of acute pancreatitis and hyperparathyroidism due to solitary parathyroid adenoma occurred in a 66-years-old woman is reported. After the excision of parathyroid adenoma the serum calcium levels and the function of the pancreas returned to normal. This suggests a cause and effect relathionship between hyperparathyroidism and acute pancreatitis.

Original languageItalian
Pages (from-to)451-454
Number of pages4
JournalMinerva Chirurgica
Volume54
Issue number6
Publication statusPublished - Jun 1999

Fingerprint

Hyperparathyroidism
Pancreatitis
Parathyroid Neoplasms
Hypercalcemia
Parathyroid Diseases
Trypsinogen
Calcium
Pancreatic Diseases
Enzyme Precursors
Hydrolases
Serum
Pancreas
Carrier Proteins

ASJC Scopus subject areas

  • Surgery

Cite this

Boneschi, M., Erba, M., Beretta, L., Miani, S., & Bortolani, E. M. (1999). Iperparatiroidismo primitivo e pancreatite acuta. Una rara associazione clinica. Minerva Chirurgica, 54(6), 451-454.

Iperparatiroidismo primitivo e pancreatite acuta. Una rara associazione clinica. / Boneschi, M.; Erba, M.; Beretta, L.; Miani, S.; Bortolani, E. M.

In: Minerva Chirurgica, Vol. 54, No. 6, 06.1999, p. 451-454.

Research output: Contribution to journalArticle

Boneschi, M, Erba, M, Beretta, L, Miani, S & Bortolani, EM 1999, 'Iperparatiroidismo primitivo e pancreatite acuta. Una rara associazione clinica', Minerva Chirurgica, vol. 54, no. 6, pp. 451-454.
Boneschi, M. ; Erba, M. ; Beretta, L. ; Miani, S. ; Bortolani, E. M. / Iperparatiroidismo primitivo e pancreatite acuta. Una rara associazione clinica. In: Minerva Chirurgica. 1999 ; Vol. 54, No. 6. pp. 451-454.
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