Hyperpigmented linear striae appeared on the trunk of a 65-year old man with a 7-year history of Hodgkin's disease. He had been treated for a few months with a cumulative bleomycin dose of 112 mg. Streaking was first noted some weeks after the onset of a very intense pruritus. Biopsy specimens showed melanotic hyperpigmentation with no change in the morphology of the skin. We think that bleomycin, cumulated in the skin because of scratching-induced vasodilatation, might slow down the epidermal turnover time and so it might allow a longer period of contact between keratinocytes and melanocytes. Moreover, this might cause an increase in the transfer of melanosomes to epidermal cells. Therapy with cimetidine in a single daily dose of 800 mg reduced the intensity of itching for several months.
|Number of pages||3|
|Journal||Giornale Italiano di Dermatologia e Venereologia|
|Publication status||Published - 1988|
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