Hyperplastic, dysplastic, and neoplastic enterochromaffin-like-cell proliferations of the gastric mucosa: Classification and histogenesis

Research output: Contribution to journalArticle

Abstract

Endocrine cells of the gastric oxyntic mucosa, and especially the enterochromaffin-like (ECL) cells, are the progenitors of gastrin-promoted proliferative lesions whose tumorigenic potential largely depends on the background condition in which they arise. Hypertrophic gastropathy due to the familial multiple endocrine neoplasia (MEN-1)-associated or sporadic Zollinger-Ellison syndrome (ZES), diffuse chronic atrophic gastritis restricted to the corpus-fundus (type A CAG), with or without associated pernicious anemia, and Helicobacter pylori-related multifocal chronic atrophic gastritis are the usual background for such growths. The endocrine cell lesions have been classified as pseudohyperplasia (cell clustering unassociated with cell proliferation), hyperplasia (diffuse, linear, micronodular, adenomatoid), dysplasia (enlarged, adenomatous or fused micronodules, microinfiltration, nodular growth), and neoplasia (intramucosal or invasive carcinoids). The entire spectrum of endocrine cell proliferation, from hyperplasia to dysplasia and neoplasia, has been observed in MEN-ZES and diffuse type A CAG. Both hyperplastic and pseudohyperplastic changes occur with some frequency in the H. pylori-related chronic gastritis associated with ulcer disease or dyspepsia. However, because no progression to dysplastic or neoplastic lesions has thus far been documented in these latter conditions, their role in gastric endocrine cell tumorigenesis appears negligible.

Original languageEnglish
JournalAmerican Journal of Surgical Pathology
Volume19
Issue numberSUPPL. 1
Publication statusPublished - 1995

Keywords

  • Carcinoids
  • Chronic atrophic gastritis
  • Dysplasia
  • ECL cells
  • Gastric endocrine growths
  • Hypergastrinemia
  • Hyperplasia
  • Multiple endocrine neoplasia
  • Neoplasia
  • Zollinger-Ellison syndrome

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Fingerprint Dive into the research topics of 'Hyperplastic, dysplastic, and neoplastic enterochromaffin-like-cell proliferations of the gastric mucosa: Classification and histogenesis'. Together they form a unique fingerprint.

  • Cite this