Hyperprolactinemia and bone

Luigi di Filippo, Mauro Doga, Eugenia Resmini, Andrea Giustina

Research output: Contribution to journalReview articlepeer-review


Prolactin (PRL) has direct and indirect effects on bone metabolism. Experimental studies showed that in the presence of high PRL levels bone resorption was increased as well as bone formation was suppressed. Increased PRL levels in humans caused a reduction in sex hormone levels which turn may have detrimental effects on bone. Patients with hyperprolactinemia did have often decreased bone mineral density as well as an increased risk of fractures. Since PRL control may be relevant to bone health it is a clinical open issue the inclusion of skeletal health in future guidelines as indication to proactive screening, prevention and treatment particularly in high risk patients such as hyperprolactinemic women after menopause and patients with drug induced hyperprolactinemia.

Original languageEnglish
Pages (from-to)314-321
Number of pages8
Issue number3
Publication statusPublished - Jun 1 2020


  • Antipsychotic drugs
  • Bone density
  • Bone metabolism
  • Hyperprolactinemia
  • Osteoporosis
  • Prolactin
  • Vertebral fractures

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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