Hyperreflective dots: A new spectral-domain optical coherence tomography entity for follow-up and prognosis in exudative age-related macular degeneration

Gabriel Coscas, Umberto De Benedetto, Florence Coscas, Concetta I. Li Calzi, Sabrina Vismara, Françoise Roudot-Thoraval, Francesco Bandello, Eric Souied

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: Spectral-domain optical coherence tomography (SD-OCT) enables high-resolution analysis of retinal layers and previously unseen hyperreflective dots (HRD). HRD morphological characteristics, evolution, possible origin and prognostic value are discussed. Methods: We conducted a prospective study of 100 patients with exudative age-related macular degeneration (AMD), who were treated and followed up with monthly imaging examinations. Statistical correlations between visual acuity (VA) and pre-/post- treatment HRD characteristics were evaluated. Results: HRD were present in all cases, mainly in the outer retinal layers but also elsewhere. After treatment, HRD regressed in a few days, 1 month (p <0.04) and 3 months (p <0.01). Regression was evident in all VA and morphological subsets. Resolution was associated with better final VA (p <0.001). Conclusions: Presence of initial/recurrent HRD, rapid treatment response and the growing role that early biological inflammatory reaction plays in AMD suggests HRD are activated microglia cells. The correlation between VA and HRD could make HRD a clinical marker for early decisions about treatment and retreatment.

Original languageEnglish
Pages (from-to)32-37
Number of pages6
JournalOphthalmologica
Volume229
Issue number1
DOIs
Publication statusPublished - Dec 2012

Keywords

  • Anti-vascular endothelial growth factor treatment
  • Exudative age-related macular degeneration
  • Hyperreflective dots
  • Spectral-domain optical coherence tomography

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

Fingerprint Dive into the research topics of 'Hyperreflective dots: A new spectral-domain optical coherence tomography entity for follow-up and prognosis in exudative age-related macular degeneration'. Together they form a unique fingerprint.

Cite this