Hypersensitivity reactions to complementary and alternative medicine products

Maria Teresa Ventura, Marinella Viola, Gianfranco Calogiuri, Francesco Gaeta, Oronzo Pesole, Antonino Romano

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Complementary and alternative medicine (CAM) is becoming increasingly popular, and is often used for treating hypersensitivity diseases. Virtually all alternative remedies can cause hypersensitivity reactions, but the most frequently involved ones are tea tree oil, members of the Compositae family, propolis, oils used in aromatherapy, substances responsible for photosensitization, and metal-containing compounds. The main target organ is skin, with manifestations ranging from contact dermatitis (the most common) to urticaria-angioedema, maculopapular eruptions, photosensitivity reactions, and the Stevens-Johnson syndrome. Other types of reactions are possible, including respiratory and anaphylactic ones. Different pathogenic mechanisms have been suggested for CAM product reactions, including immunologic ones. Basophils and mast cells participate in IgE-mediated reactions through the release of mediators like histamine and tryptase, whereas a T-cell-mediated pathogenic mechanism is involved in most delayed reactions, particularly contact dermatitis and maculopapular eruptions. Skin tests and serum specific IgE assays are carried out to diagnose immediate hypersensitivity reactions, while patch tests and lymphocyte transformation tests are usually performed to evaluate delayed hypersensitivity reactions. Thus clinicians should know about the potential of CAM products for causing adverse reactions. Our study is aimed at highlighting the risk of hypersensitive reactions to CAM remedies on the basis of the numerous cases reported in the literature. Because little is known about adverse reactions to CAM products, further systematic studies and an appropriate regulation by heath authorities are necessary.

Original languageEnglish
Pages (from-to)3393-3399
Number of pages7
JournalCurrent Pharmaceutical Design
Volume12
Issue number26
DOIs
Publication statusPublished - Sep 2006

Fingerprint

Complementary Therapies
Hypersensitivity
Contact Dermatitis
Immunoglobulin E
Tea Tree Oil
Aromatherapy
Propolis
Photosensitivity Disorders
Skin Manifestations
Tryptases
Immediate Hypersensitivity
Angioedema
Stevens-Johnson Syndrome
Asteraceae
Patch Tests
Basophils
Urticaria
Delayed Hypersensitivity
Lymphocyte Activation
Skin Tests

Keywords

  • Contact dermatitis
  • Herbal remedies
  • Hypersensitivity reactions
  • Metals
  • Patch tests
  • Specific IgE

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Hypersensitivity reactions to complementary and alternative medicine products. / Ventura, Maria Teresa; Viola, Marinella; Calogiuri, Gianfranco; Gaeta, Francesco; Pesole, Oronzo; Romano, Antonino.

In: Current Pharmaceutical Design, Vol. 12, No. 26, 09.2006, p. 3393-3399.

Research output: Contribution to journalArticle

Ventura, Maria Teresa ; Viola, Marinella ; Calogiuri, Gianfranco ; Gaeta, Francesco ; Pesole, Oronzo ; Romano, Antonino. / Hypersensitivity reactions to complementary and alternative medicine products. In: Current Pharmaceutical Design. 2006 ; Vol. 12, No. 26. pp. 3393-3399.
@article{54b0786037e64ad3b9cc046c3b1f6f40,
title = "Hypersensitivity reactions to complementary and alternative medicine products",
abstract = "Complementary and alternative medicine (CAM) is becoming increasingly popular, and is often used for treating hypersensitivity diseases. Virtually all alternative remedies can cause hypersensitivity reactions, but the most frequently involved ones are tea tree oil, members of the Compositae family, propolis, oils used in aromatherapy, substances responsible for photosensitization, and metal-containing compounds. The main target organ is skin, with manifestations ranging from contact dermatitis (the most common) to urticaria-angioedema, maculopapular eruptions, photosensitivity reactions, and the Stevens-Johnson syndrome. Other types of reactions are possible, including respiratory and anaphylactic ones. Different pathogenic mechanisms have been suggested for CAM product reactions, including immunologic ones. Basophils and mast cells participate in IgE-mediated reactions through the release of mediators like histamine and tryptase, whereas a T-cell-mediated pathogenic mechanism is involved in most delayed reactions, particularly contact dermatitis and maculopapular eruptions. Skin tests and serum specific IgE assays are carried out to diagnose immediate hypersensitivity reactions, while patch tests and lymphocyte transformation tests are usually performed to evaluate delayed hypersensitivity reactions. Thus clinicians should know about the potential of CAM products for causing adverse reactions. Our study is aimed at highlighting the risk of hypersensitive reactions to CAM remedies on the basis of the numerous cases reported in the literature. Because little is known about adverse reactions to CAM products, further systematic studies and an appropriate regulation by heath authorities are necessary.",
keywords = "Contact dermatitis, Herbal remedies, Hypersensitivity reactions, Metals, Patch tests, Specific IgE",
author = "Ventura, {Maria Teresa} and Marinella Viola and Gianfranco Calogiuri and Francesco Gaeta and Oronzo Pesole and Antonino Romano",
year = "2006",
month = "9",
doi = "10.2174/138161206778194079",
language = "English",
volume = "12",
pages = "3393--3399",
journal = "Current Pharmaceutical Design",
issn = "1381-6128",
publisher = "Bentham Science Publishers B.V.",
number = "26",

}

TY - JOUR

T1 - Hypersensitivity reactions to complementary and alternative medicine products

AU - Ventura, Maria Teresa

AU - Viola, Marinella

AU - Calogiuri, Gianfranco

AU - Gaeta, Francesco

AU - Pesole, Oronzo

AU - Romano, Antonino

PY - 2006/9

Y1 - 2006/9

N2 - Complementary and alternative medicine (CAM) is becoming increasingly popular, and is often used for treating hypersensitivity diseases. Virtually all alternative remedies can cause hypersensitivity reactions, but the most frequently involved ones are tea tree oil, members of the Compositae family, propolis, oils used in aromatherapy, substances responsible for photosensitization, and metal-containing compounds. The main target organ is skin, with manifestations ranging from contact dermatitis (the most common) to urticaria-angioedema, maculopapular eruptions, photosensitivity reactions, and the Stevens-Johnson syndrome. Other types of reactions are possible, including respiratory and anaphylactic ones. Different pathogenic mechanisms have been suggested for CAM product reactions, including immunologic ones. Basophils and mast cells participate in IgE-mediated reactions through the release of mediators like histamine and tryptase, whereas a T-cell-mediated pathogenic mechanism is involved in most delayed reactions, particularly contact dermatitis and maculopapular eruptions. Skin tests and serum specific IgE assays are carried out to diagnose immediate hypersensitivity reactions, while patch tests and lymphocyte transformation tests are usually performed to evaluate delayed hypersensitivity reactions. Thus clinicians should know about the potential of CAM products for causing adverse reactions. Our study is aimed at highlighting the risk of hypersensitive reactions to CAM remedies on the basis of the numerous cases reported in the literature. Because little is known about adverse reactions to CAM products, further systematic studies and an appropriate regulation by heath authorities are necessary.

AB - Complementary and alternative medicine (CAM) is becoming increasingly popular, and is often used for treating hypersensitivity diseases. Virtually all alternative remedies can cause hypersensitivity reactions, but the most frequently involved ones are tea tree oil, members of the Compositae family, propolis, oils used in aromatherapy, substances responsible for photosensitization, and metal-containing compounds. The main target organ is skin, with manifestations ranging from contact dermatitis (the most common) to urticaria-angioedema, maculopapular eruptions, photosensitivity reactions, and the Stevens-Johnson syndrome. Other types of reactions are possible, including respiratory and anaphylactic ones. Different pathogenic mechanisms have been suggested for CAM product reactions, including immunologic ones. Basophils and mast cells participate in IgE-mediated reactions through the release of mediators like histamine and tryptase, whereas a T-cell-mediated pathogenic mechanism is involved in most delayed reactions, particularly contact dermatitis and maculopapular eruptions. Skin tests and serum specific IgE assays are carried out to diagnose immediate hypersensitivity reactions, while patch tests and lymphocyte transformation tests are usually performed to evaluate delayed hypersensitivity reactions. Thus clinicians should know about the potential of CAM products for causing adverse reactions. Our study is aimed at highlighting the risk of hypersensitive reactions to CAM remedies on the basis of the numerous cases reported in the literature. Because little is known about adverse reactions to CAM products, further systematic studies and an appropriate regulation by heath authorities are necessary.

KW - Contact dermatitis

KW - Herbal remedies

KW - Hypersensitivity reactions

KW - Metals

KW - Patch tests

KW - Specific IgE

UR - http://www.scopus.com/inward/record.url?scp=33748555856&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33748555856&partnerID=8YFLogxK

U2 - 10.2174/138161206778194079

DO - 10.2174/138161206778194079

M3 - Article

C2 - 17017933

AN - SCOPUS:33748555856

VL - 12

SP - 3393

EP - 3399

JO - Current Pharmaceutical Design

JF - Current Pharmaceutical Design

SN - 1381-6128

IS - 26

ER -