Hypersensitivity reactions to proton pump inhibitors in childhood

Francesca Mori, Fabrizio Franceschini, Francesca Saretta, Annamaria Bianchi, Paolo Bottau, Silvia Caimmi, Giuseppe Crisafulli, Lucia Liotti, Claudia Paglialunga, Carlo Caffarelli

Research output: Contribution to journalArticlepeer-review


Hypersensitivity reactions (HRs) to proton pump inhibitors (PPIs) are mainly described in adults. Anyway, increased use of PPIs in childhood has been observed in recent years. In the literature, only case reports are published on children. Most of the PPI HRs are IgE-mediated. Skin test concentrations and allergy workup protocols used for adults are also applied in children. This study underlies that multicentric pediatric studies focusing on PPI reactions in children are needed.

Original languageEnglish
Pages (from-to)29-32
Number of pages4
JournalPediatric Allergy and Immunology
Issue numberS26
Publication statusPublished - Nov 2020


  • childhood
  • drug hypersensitivity
  • proton pump inhibitors

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Immunology and Allergy
  • Immunology


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