Hypersensitivity to lipid mobilizing agents in essential fatty acid (EFA) deficient rats

A. Bizzi, E. Veneroni, S. Garattini, L. Puglisi, R. Paoletti

Research output: Contribution to journalArticlepeer-review

Abstract

Essential fatty acid (EFA) -deficient rats showed a higher sensitivity to lipolytic agents than control animals. Norepinephrine released more free fatty acid in vivo and in vitro, both from adipose tissue slices and isolated fat cells. Similarly, theophylline and cyclic 3′, 5′ AMP (dibutyryl ester) were more active on EFA-deficient fat cells than on control cells. Also, the combination of norepinephrine with theophylline was more effective in EFA-deficient fat cells. PGE1 was able to inhibit the lipolytic effect of norepinephrine on EFA-deficient fat cells as well as on controls. The results are discussed with reference to the possible physiological role of EFA as precursors of prostaglandins.

Original languageEnglish
Pages (from-to)48-52
Number of pages5
JournalEuropean Journal of Pharmacology
Volume2
Issue number1
Publication statusPublished - Oct 1967

Keywords

  • Cyclic 3′, 5′ AMP (dibutyryl ester) Prostaglandins
  • Free fatty acids Glycerol
  • Isolated fat cells
  • Norepinephrine Adipose tissue
  • Theophylline Essential fatty acid deficiency

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

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