Abstract
Nonsteroidal anti-inflammatory drugs (NSAIDs) are responsible for 21-25% of reported adverse drug events which include immunological and nonimmunological hypersensitivity reactions. This study presents up-to-date information on pathomechanisms, clinical spectrum, diagnostic tools and management of hypersensitivity reactions to NSAIDs. Clinically, NSAID hypersensitivity is particularly manifested by bronchial asthma, rhinosinusitis, anaphylaxis or urticaria and variety of late cutaneous and organ-specific reactions. Diagnosis of hypersensitivity to a NSAID includes understanding of the underlying mechanism and is necessary for prevention and management. A stepwise approach to the diagnosis of hypersensitivity to NSAIDs is proposed, including clinical history, in vitro testing and/or provocation test with a culprit or alternative drug depending on the type of the reaction. The diagnostic process should result in providing the patient with written information both on forbidden and on alternative drugs.
| Original language | English |
|---|---|
| Pages (from-to) | 818-829 |
| Number of pages | 12 |
| Journal | Allergy: European Journal of Allergy and Clinical Immunology |
| Volume | 66 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 2011 |
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Keywords
- aspirin hypersensitivity
- drug allergy
- nonsteroidal anti-inflammatory drugs
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
Cite this
Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) - Classification, diagnosis and management : Review of the EAACI/ENDA and GA2LEN/HANNA. / Kowalski, M. L.; Makowska, J. S.; Blanca, M.; Bavbek, S.; Bochenek, G.; Bousquet, J.; Bousquet, P.; Celik, G.; Demoly, P.; Gomes, E. R.; Nizankowska-Mogilnicka, E.; Romano, A.; Sanchez-Borges, M.; Sanz, M.; Torres, M. J.; De Weck, A.; Szczeklik, A.; Brockow, K.
In: Allergy: European Journal of Allergy and Clinical Immunology, Vol. 66, No. 7, 07.2011, p. 818-829.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) - Classification, diagnosis and management
T2 - Review of the EAACI/ENDA and GA2LEN/HANNA
AU - Kowalski, M. L.
AU - Makowska, J. S.
AU - Blanca, M.
AU - Bavbek, S.
AU - Bochenek, G.
AU - Bousquet, J.
AU - Bousquet, P.
AU - Celik, G.
AU - Demoly, P.
AU - Gomes, E. R.
AU - Nizankowska-Mogilnicka, E.
AU - Romano, A.
AU - Sanchez-Borges, M.
AU - Sanz, M.
AU - Torres, M. J.
AU - De Weck, A.
AU - Szczeklik, A.
AU - Brockow, K.
PY - 2011/7
Y1 - 2011/7
N2 - Nonsteroidal anti-inflammatory drugs (NSAIDs) are responsible for 21-25% of reported adverse drug events which include immunological and nonimmunological hypersensitivity reactions. This study presents up-to-date information on pathomechanisms, clinical spectrum, diagnostic tools and management of hypersensitivity reactions to NSAIDs. Clinically, NSAID hypersensitivity is particularly manifested by bronchial asthma, rhinosinusitis, anaphylaxis or urticaria and variety of late cutaneous and organ-specific reactions. Diagnosis of hypersensitivity to a NSAID includes understanding of the underlying mechanism and is necessary for prevention and management. A stepwise approach to the diagnosis of hypersensitivity to NSAIDs is proposed, including clinical history, in vitro testing and/or provocation test with a culprit or alternative drug depending on the type of the reaction. The diagnostic process should result in providing the patient with written information both on forbidden and on alternative drugs.
AB - Nonsteroidal anti-inflammatory drugs (NSAIDs) are responsible for 21-25% of reported adverse drug events which include immunological and nonimmunological hypersensitivity reactions. This study presents up-to-date information on pathomechanisms, clinical spectrum, diagnostic tools and management of hypersensitivity reactions to NSAIDs. Clinically, NSAID hypersensitivity is particularly manifested by bronchial asthma, rhinosinusitis, anaphylaxis or urticaria and variety of late cutaneous and organ-specific reactions. Diagnosis of hypersensitivity to a NSAID includes understanding of the underlying mechanism and is necessary for prevention and management. A stepwise approach to the diagnosis of hypersensitivity to NSAIDs is proposed, including clinical history, in vitro testing and/or provocation test with a culprit or alternative drug depending on the type of the reaction. The diagnostic process should result in providing the patient with written information both on forbidden and on alternative drugs.
KW - aspirin hypersensitivity
KW - drug allergy
KW - nonsteroidal anti-inflammatory drugs
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UR - http://www.scopus.com/inward/citedby.url?scp=79958161182&partnerID=8YFLogxK
U2 - 10.1111/j.1398-9995.2011.02557.x
DO - 10.1111/j.1398-9995.2011.02557.x
M3 - Article
C2 - 21631520
AN - SCOPUS:79958161182
VL - 66
SP - 818
EP - 829
JO - Allergy: European Journal of Allergy and Clinical Immunology
JF - Allergy: European Journal of Allergy and Clinical Immunology
SN - 0105-4538
IS - 7
ER -