Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) - Classification, diagnosis and management

Review of the EAACI/ENDA and GA2LEN/HANNA

M. L. Kowalski, J. S. Makowska, M. Blanca, S. Bavbek, G. Bochenek, J. Bousquet, P. Bousquet, G. Celik, P. Demoly, E. R. Gomes, E. Nizankowska-Mogilnicka, A. Romano, M. Sanchez-Borges, M. Sanz, M. J. Torres, A. De Weck, A. Szczeklik, K. Brockow

Research output: Contribution to journalArticle

261 Citations (Scopus)

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) are responsible for 21-25% of reported adverse drug events which include immunological and nonimmunological hypersensitivity reactions. This study presents up-to-date information on pathomechanisms, clinical spectrum, diagnostic tools and management of hypersensitivity reactions to NSAIDs. Clinically, NSAID hypersensitivity is particularly manifested by bronchial asthma, rhinosinusitis, anaphylaxis or urticaria and variety of late cutaneous and organ-specific reactions. Diagnosis of hypersensitivity to a NSAID includes understanding of the underlying mechanism and is necessary for prevention and management. A stepwise approach to the diagnosis of hypersensitivity to NSAIDs is proposed, including clinical history, in vitro testing and/or provocation test with a culprit or alternative drug depending on the type of the reaction. The diagnostic process should result in providing the patient with written information both on forbidden and on alternative drugs.

Original languageEnglish
Pages (from-to)818-829
Number of pages12
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume66
Issue number7
DOIs
Publication statusPublished - Jul 2011

Fingerprint

Hypersensitivity
Anti-Inflammatory Agents
Pharmaceutical Preparations
Drug Hypersensitivity
Urticaria
Anaphylaxis
Drug-Related Side Effects and Adverse Reactions
Asthma
Skin

Keywords

  • aspirin hypersensitivity
  • drug allergy
  • nonsteroidal anti-inflammatory drugs

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) - Classification, diagnosis and management : Review of the EAACI/ENDA and GA2LEN/HANNA. / Kowalski, M. L.; Makowska, J. S.; Blanca, M.; Bavbek, S.; Bochenek, G.; Bousquet, J.; Bousquet, P.; Celik, G.; Demoly, P.; Gomes, E. R.; Nizankowska-Mogilnicka, E.; Romano, A.; Sanchez-Borges, M.; Sanz, M.; Torres, M. J.; De Weck, A.; Szczeklik, A.; Brockow, K.

In: Allergy: European Journal of Allergy and Clinical Immunology, Vol. 66, No. 7, 07.2011, p. 818-829.

Research output: Contribution to journalArticle

Kowalski, ML, Makowska, JS, Blanca, M, Bavbek, S, Bochenek, G, Bousquet, J, Bousquet, P, Celik, G, Demoly, P, Gomes, ER, Nizankowska-Mogilnicka, E, Romano, A, Sanchez-Borges, M, Sanz, M, Torres, MJ, De Weck, A, Szczeklik, A & Brockow, K 2011, 'Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) - Classification, diagnosis and management: Review of the EAACI/ENDA and GA2LEN/HANNA', Allergy: European Journal of Allergy and Clinical Immunology, vol. 66, no. 7, pp. 818-829. https://doi.org/10.1111/j.1398-9995.2011.02557.x
Kowalski, M. L. ; Makowska, J. S. ; Blanca, M. ; Bavbek, S. ; Bochenek, G. ; Bousquet, J. ; Bousquet, P. ; Celik, G. ; Demoly, P. ; Gomes, E. R. ; Nizankowska-Mogilnicka, E. ; Romano, A. ; Sanchez-Borges, M. ; Sanz, M. ; Torres, M. J. ; De Weck, A. ; Szczeklik, A. ; Brockow, K. / Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) - Classification, diagnosis and management : Review of the EAACI/ENDA and GA2LEN/HANNA. In: Allergy: European Journal of Allergy and Clinical Immunology. 2011 ; Vol. 66, No. 7. pp. 818-829.
@article{de8c4edb99fd4f419cbff3802fd978d0,
title = "Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) - Classification, diagnosis and management: Review of the EAACI/ENDA and GA2LEN/HANNA",
abstract = "Nonsteroidal anti-inflammatory drugs (NSAIDs) are responsible for 21-25{\%} of reported adverse drug events which include immunological and nonimmunological hypersensitivity reactions. This study presents up-to-date information on pathomechanisms, clinical spectrum, diagnostic tools and management of hypersensitivity reactions to NSAIDs. Clinically, NSAID hypersensitivity is particularly manifested by bronchial asthma, rhinosinusitis, anaphylaxis or urticaria and variety of late cutaneous and organ-specific reactions. Diagnosis of hypersensitivity to a NSAID includes understanding of the underlying mechanism and is necessary for prevention and management. A stepwise approach to the diagnosis of hypersensitivity to NSAIDs is proposed, including clinical history, in vitro testing and/or provocation test with a culprit or alternative drug depending on the type of the reaction. The diagnostic process should result in providing the patient with written information both on forbidden and on alternative drugs.",
keywords = "aspirin hypersensitivity, drug allergy, nonsteroidal anti-inflammatory drugs",
author = "Kowalski, {M. L.} and Makowska, {J. S.} and M. Blanca and S. Bavbek and G. Bochenek and J. Bousquet and P. Bousquet and G. Celik and P. Demoly and Gomes, {E. R.} and E. Nizankowska-Mogilnicka and A. Romano and M. Sanchez-Borges and M. Sanz and Torres, {M. J.} and {De Weck}, A. and A. Szczeklik and K. Brockow",
year = "2011",
month = "7",
doi = "10.1111/j.1398-9995.2011.02557.x",
language = "English",
volume = "66",
pages = "818--829",
journal = "Allergy: European Journal of Allergy and Clinical Immunology",
issn = "0105-4538",
publisher = "Wiley-Blackwell",
number = "7",

}

TY - JOUR

T1 - Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) - Classification, diagnosis and management

T2 - Review of the EAACI/ENDA and GA2LEN/HANNA

AU - Kowalski, M. L.

AU - Makowska, J. S.

AU - Blanca, M.

AU - Bavbek, S.

AU - Bochenek, G.

AU - Bousquet, J.

AU - Bousquet, P.

AU - Celik, G.

AU - Demoly, P.

AU - Gomes, E. R.

AU - Nizankowska-Mogilnicka, E.

AU - Romano, A.

AU - Sanchez-Borges, M.

AU - Sanz, M.

AU - Torres, M. J.

AU - De Weck, A.

AU - Szczeklik, A.

AU - Brockow, K.

PY - 2011/7

Y1 - 2011/7

N2 - Nonsteroidal anti-inflammatory drugs (NSAIDs) are responsible for 21-25% of reported adverse drug events which include immunological and nonimmunological hypersensitivity reactions. This study presents up-to-date information on pathomechanisms, clinical spectrum, diagnostic tools and management of hypersensitivity reactions to NSAIDs. Clinically, NSAID hypersensitivity is particularly manifested by bronchial asthma, rhinosinusitis, anaphylaxis or urticaria and variety of late cutaneous and organ-specific reactions. Diagnosis of hypersensitivity to a NSAID includes understanding of the underlying mechanism and is necessary for prevention and management. A stepwise approach to the diagnosis of hypersensitivity to NSAIDs is proposed, including clinical history, in vitro testing and/or provocation test with a culprit or alternative drug depending on the type of the reaction. The diagnostic process should result in providing the patient with written information both on forbidden and on alternative drugs.

AB - Nonsteroidal anti-inflammatory drugs (NSAIDs) are responsible for 21-25% of reported adverse drug events which include immunological and nonimmunological hypersensitivity reactions. This study presents up-to-date information on pathomechanisms, clinical spectrum, diagnostic tools and management of hypersensitivity reactions to NSAIDs. Clinically, NSAID hypersensitivity is particularly manifested by bronchial asthma, rhinosinusitis, anaphylaxis or urticaria and variety of late cutaneous and organ-specific reactions. Diagnosis of hypersensitivity to a NSAID includes understanding of the underlying mechanism and is necessary for prevention and management. A stepwise approach to the diagnosis of hypersensitivity to NSAIDs is proposed, including clinical history, in vitro testing and/or provocation test with a culprit or alternative drug depending on the type of the reaction. The diagnostic process should result in providing the patient with written information both on forbidden and on alternative drugs.

KW - aspirin hypersensitivity

KW - drug allergy

KW - nonsteroidal anti-inflammatory drugs

UR - http://www.scopus.com/inward/record.url?scp=79958161182&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79958161182&partnerID=8YFLogxK

U2 - 10.1111/j.1398-9995.2011.02557.x

DO - 10.1111/j.1398-9995.2011.02557.x

M3 - Article

VL - 66

SP - 818

EP - 829

JO - Allergy: European Journal of Allergy and Clinical Immunology

JF - Allergy: European Journal of Allergy and Clinical Immunology

SN - 0105-4538

IS - 7

ER -