Nadwrażliwość na niesteroidowe leki przeciwzapalne (NLPZ) - klasyfikacja, rozpoznawanie i leczenie: Przegla{ogonek}d EAACI/ENDA# i GA2LEN/HANNA

Translated title of the contribution: Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) - classification, diagnosis and management: Review of the EAACI/ENDA# and GA2LEN/HANNA

M. L. Kowalski, J. S. Makowska, M. Blanca, S. Bavbek, G. Bochenek, J. Bousquet, P. Bousquet, G. Celik, P. Demoly, E. R. Gomes, E. Nizankowska-Mogilnicka, A. Romano, M. Sanchez-Borges, M. Sanz, M. J. Torres, A. de Weck, A. Szczeklik, K. Brockow

Research output: Contribution to journalArticlepeer-review

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) are responsible for 21-25% of reported adverse drug events which include immunological and nonimmunological hypersensitivity reactions. This study presents up-to-date information on pathomechanisms, clinical spectrum, diagnostic tools and management of hyper-sensitivity reactions to NSAIDs. Clinically, NSAID hypersensitivity is particularly manifested by bronchial asthma, rhinosinusitis, anaphylaxis or urticaria and variety of late cutaneous and organ-specific reactions. Diagnosis of hypersensitivity to a NSAID includes understanding of the underlying mechanism and is necessary for prevention and management. A stepwise approach to the diagnosis of hypersensitivity to NSAIDs is proposed, including clinical history, in vitro testing and/or provocation test with a culprit or alternative drug depending on the type of the reaction. The diagnostic process should result in providing the patient with written information both on forbidden and on alternative drugs.

Translated title of the contributionHypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) - classification, diagnosis and management: Review of the EAACI/ENDA# and GA2LEN/HANNA
Original languagePolish
Pages (from-to)57-70
Number of pages14
JournalAlergia Astma Immunologia
Volume16
Issue number2
Publication statusPublished - Jun 2011

Keywords

  • Aspirin hypersensitivity
  • Drug allergy
  • Nonsteroidal anti-inflammatory drugs

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine

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