Ipersensibilità agli anticoagulanti orali: Descrizione di un caso

Translated title of the contribution: Hypersensitivity to oral anticoagulants: A case report

M. M. Patella, P. E. Russo, D. De Lucia, M. Margaglione, D. Colaizzo, A. Iacono

Research output: Contribution to journalArticlepeer-review

Abstract

We report a case regarding a 71 year-old Caucasian man with NYHA functional class III congestive heart failure, who was under warfarin treatment due to left ventricular thrombosis. After a few days, although the drug was not overdosed, the INR increased up to 11.68. Normal values were reestablished only after a 20-day pharmacological wash-out. Surprisingly, no episode of major or minor bleeding occurred. Gene typing of cytochrome P450 CYP2C9, a liver enzyme responsible for warfarin metabolism, showed that the patient was a carrier of both the mutant alleles (CYP2C9*2/*3) of this enzyme. This genetic defect caused a reduced catabolism of S-warfarin and excessive anticoagulation.

Translated title of the contributionHypersensitivity to oral anticoagulants: A case report
Original languageItalian
Pages (from-to)303-306
Number of pages4
JournalItalian Heart Journal Supplement
Volume2
Issue number3
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Hypersensitivity to oral anticoagulants: A case report'. Together they form a unique fingerprint.

Cite this