Hypersensitivity to tomato (Lycopersicon esculentum) in peach-allergic patients: Rpru p 3 and rpru p 1 are predictive of symptom severity

A. Mascheri, L. Farioli, V. Pravettoni, M. Piantanida, C. Stafylaraki, J. Scibilia, C. Mirone, D. Preziosi, M. Nichelatti, Elide A. Pastorello

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The role of allergens in the severity of tomato allergy symptoms has not yet been studied. Objectives: To evaluate the relationship between severe allergic reactions to peach and tomato and between tomato allergy symptoms and the pattern of IgE positivity for rPru p 1, rPru p 3, rPru p 4, rBet v 1, rBet v 2, rBet v 4, rPhl p 1, and rPhl p 12 in order to identify the role of recombinant allergens in the severity of reactions to tomato. Methods: We studied peach-allergic patients with clinical reactions to tomato by performing an open food challenge, skin prick test, and determination of serum specific IgE to tomato and to recombinant peach, birch, and grass allergens. Statistical analysis was carried out to evaluate the relationship between the severity of tomato symptoms and IgE positivity to the different allergens and to peach-induced symptoms. Results: We found a significant association between severe reactions to tomato and severe reactions to peach (P=.017) and levels of IgE to rPru p 3 (P=.029) and between mild tomato allergy symptoms and levels of IgE to rPru p 1 (P=.047), anti-rBet v 1 (P=.0414), anti-rBet v 2 (P=.0457), and Phleum pratense (P=.0022). Conclusion: We observed a significant relationship between peach and symptoms of tomato allergy. IgE positivity for rPru p 3 seems to be a surrogate biochemical marker for severe tomato allergy, whereas the presence of anti-rPru p 1 IgE may be an indicator of mild tomato allergy.

Original languageEnglish
Pages (from-to)183-189
Number of pages7
JournalJournal of investigational allergology & clinical immunology : official organ of the International Association of Asthmology (INTERASMA) and Sociedad Latinoamericana de Alergia e Inmunología
Volume25
Issue number3
Publication statusPublished - Jun 20 2015

Keywords

  • Lipid transfer protein
  • LTP
  • Peach allergy
  • Pru p 1
  • Pru p 3

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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