Hypertension and heart failure: Role of neurohormonal mechanisms

Massimo Volpe, E. Pagannone, G. Tocci, S. Rubattu

Research output: Contribution to journalArticlepeer-review


Hypertension represents the most common associated cause of heart failure, and it is frequently involved in the pathogenesis of left ventricular dysfunction and its progression towards congestive heart failure. A common pathophysiological link of hypertension to heart failure is represented by the abnormalities of the neurohormonal profile and its impact on cardiac function, systemic hemodynamics and salt/water balance. This article synthetically reviews this aspect together with a specific analysis of the significance of measurements of neurohormones for diagnosis and prognostic stratification in heart failure.

Original languageEnglish
Pages (from-to)603-610
Number of pages8
JournalClinical and Experimental Hypertension
Issue number7-8
Publication statusPublished - Oct 2004


  • Angiotensin II
  • Blood pressure
  • Natriuretic peptides
  • Ventricular function

ASJC Scopus subject areas

  • Internal Medicine


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