Hypertension and migraine comorbidity: Prevalence and risk of cerebrovascular events: Evidence from a large, multicenter, cross-sectional survey in Italy (MIRACLES study)

Giuseppe Mancia, Enrico Agabiti Rosei, Ettore Ambrosioni, Francesco Avino, Antonio Carolei, Maurizio Daccò, Giovanni Di Giacomo, Claudio Ferri, Irene Grazioli, Gabriella Melzi, Giuseppe Nappi, Lorenzo Pinessi, Giorgio Sandrini, Bruno Trimarco, Giorgio Zanchin

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: To estimate the prevalence of hypertension-migraine comorbidity; to determine their demographic and clinical characteristics versus patients with hypertension or migraine alone; and to see whether a history of cerebrovascular events was more common in the comorbidity group. Methods: The MIRACLES, multicenter, cross-sectional, survey included 2973 patients with a known diagnosis of hypertension or migraine in a general practitioner setting in Italy. Results: Five hundred and seventeen patients (17%) suffered from hypertension-migraine comorbidity, whereas 1271 (43%) suffered from hypertension only, and 1185 (40%) from migraine only. In the comorbidity group, the onset of comorbidity occurred at about 45 years of age, with migraine starting significantly later than in the migraine-only group, and hypertension significantly before than in the hypertension-only group; a familial history of both hypertension and migraine had a significantly higher frequency as compared with the hypertension and migraine group. Compared to hypertension (3.1%) and migraine (0.7%), the comorbidity group had a higher prevalence (4.4%) of history of cerebrovascular events, with an odds ratio of a predicted history of stroke/transient ischemic attack (TIA) of 1.76 [95% confidence interval (CI) 1.01-3.07] compared to the hypertension group. In patients without other recognized risk factors for stroke, stroke/TIA occurred more frequently in the comorbidity group, compared to the hypertension group. In the age range 40-49 years, prevalence of history of stroke/TIA was five-fold greater (4.8% in comorbidity vs. 0.9% in hypertension group). Conclusion: This cross-sectional study indicates that the prevalence of comorbidity hypertension-migraine is substantial and that patients with comorbidity have a higher probability of history of cerebrovascular events, compared to hypertensive patients.

Original languageEnglish
Pages (from-to)309-318
Number of pages10
JournalJournal of Hypertension
Volume29
Issue number2
DOIs
Publication statusPublished - Feb 2011

Keywords

  • comorbidity
  • hypertension
  • migraine
  • stroke

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

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