Hypertension exacerbates the effect of hypercholesterolemia on the myocardial microvasculature

Martin Rodriguez-Porcel, Amir Lerman, Joerg Herrmann, Robert S. Schwartz, Tatsuya Sawamura, Mario Condorelli, Claudio Napoli, Lilach O. Lerman

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Hypercholesterolemia (HC) and hypertension (HT) are both major risk factors for the development and progression of atherosclerotic heart disease, and their co-existence has been associated with an increased incidence of cardiac events in clinical studies. HC and HT are individually associated with abnormal myocardial vascular function, but whether HT exacerbates the HC-induced myocardial vascular dysfunction remains unclear. Methods: We studied in pigs the effect of renovascular HT superimposed on diet-induced HC (HC+HT) on myocardial perfusion and microvascular permeability in vivo (using electron-beam computed tomography) in response to cardiac challenge (i.v. adenosine and dobutamine). The involvement of systemic and myocardial tissue oxidative stress in vitro was assessed by oxidizability of LDL, levels of endogenous antioxidants, and tissue activities of radical-scavenger systems. Results: While in normal animals myocardial perfusion increased in response to i.v. adenosine (+36±13%, P

Original languageEnglish
Pages (from-to)213-221
Number of pages9
JournalCardiovascular Research
Volume58
Issue number1
DOIs
Publication statusPublished - May 1 2003

Keywords

  • Atherosclerosis
  • Coronary circulation
  • Hypertension
  • Microcirculation
  • Regional blood flow

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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