Hypertension reduces the number of beta-adrenergic receptors in rat brain microvessels

M. S. Magnoni, H. Kobayashi, A. Cazzaniga, F. Izumi, P. F. Spano, M. Trabucchi

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Abstract

Beta-adrenergic receptor function was measured in cerebral microvessels of spontaneously and DOCA-salt hypertensive rats using 125I-iodohydroxybenzylpindolol (IHYP). Both in genetic and in experimental hypertension, a significant decrease in the number of β-receptor sites was observed, without receptor affinity changes. These results suggest that alterations of central adrenergic regulation of small vessels may participate in the pathogenetic mechanisms leading to the development of the central hypertensive disease.

Original languageEnglish
Pages (from-to)610-613
Number of pages4
JournalCirculation
Volume67
Issue number3
Publication statusPublished - 1983

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ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Magnoni, M. S., Kobayashi, H., Cazzaniga, A., Izumi, F., Spano, P. F., & Trabucchi, M. (1983). Hypertension reduces the number of beta-adrenergic receptors in rat brain microvessels. Circulation, 67(3), 610-613.