Hypertensive heart disease and obesity: A complex interaction between hemodynamic and not hemodynamic factors

Riccardo Sarzani, Marica Bordicchia, Francesco Spannella, Paolo Dessì-Fulgheri, Massimiliano Fedecostante

Research output: Contribution to journalArticlepeer-review

Abstract

The worldwide prevalence of obesity has nearly doubled, with an increase in obesity-related cardiovascular disease and mortality. Several factors are involved in the genesis of hypertension and hypertensive heart disease (HHD) in overweight/obesity. This review is focused on bridging factors between excessive adiposity and HHD, presenting a unifying hypothesis of vascular-metabolic syndrome, where an "handicap" of the natriuretic peptide system has a central role both in adipocyte dysmetabolism as well as in increased blood pressure and HHD.

Original languageEnglish
Pages (from-to)81-87
Number of pages7
JournalHigh Blood Pressure and Cardiovascular Prevention
Volume21
Issue number2
DOIs
Publication statusPublished - 2014

Keywords

  • Adipocyte
  • Cardiovascular risk
  • Hypertensive heart disease
  • Natriuretic peptides
  • Obesity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine
  • Medicine(all)

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