TY - JOUR
T1 - Hypertensive heart disease and obesity
T2 - A complex interaction between hemodynamic and not hemodynamic factors
AU - Sarzani, Riccardo
AU - Bordicchia, Marica
AU - Spannella, Francesco
AU - Dessì-Fulgheri, Paolo
AU - Fedecostante, Massimiliano
PY - 2014
Y1 - 2014
N2 - The worldwide prevalence of obesity has nearly doubled, with an increase in obesity-related cardiovascular disease and mortality. Several factors are involved in the genesis of hypertension and hypertensive heart disease (HHD) in overweight/obesity. This review is focused on bridging factors between excessive adiposity and HHD, presenting a unifying hypothesis of vascular-metabolic syndrome, where an "handicap" of the natriuretic peptide system has a central role both in adipocyte dysmetabolism as well as in increased blood pressure and HHD.
AB - The worldwide prevalence of obesity has nearly doubled, with an increase in obesity-related cardiovascular disease and mortality. Several factors are involved in the genesis of hypertension and hypertensive heart disease (HHD) in overweight/obesity. This review is focused on bridging factors between excessive adiposity and HHD, presenting a unifying hypothesis of vascular-metabolic syndrome, where an "handicap" of the natriuretic peptide system has a central role both in adipocyte dysmetabolism as well as in increased blood pressure and HHD.
KW - Adipocyte
KW - Cardiovascular risk
KW - Hypertensive heart disease
KW - Natriuretic peptides
KW - Obesity
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U2 - 10.1007/s40292-014-0054-3
DO - 10.1007/s40292-014-0054-3
M3 - Article
C2 - 24821373
AN - SCOPUS:84904614308
VL - 21
SP - 81
EP - 87
JO - High Blood Pressure and Cardiovascular Prevention
JF - High Blood Pressure and Cardiovascular Prevention
SN - 1120-9879
IS - 2
ER -