Abstract
It has been demonstrated in vitro and in vivo that hyperthermia can enhance the cytotoxicity of some chemotherapeutic agents. The in vivo studies have demonstrated that the thermal advantage is maximized at mild temperatures such as at 40.5-43°C. Thermo-chemotherapy is widely applied in limb perfusion and intraperitoneal chemotherapy. Hypoxia in solid tumours leads to resistance to most anticancer drugs and appears to accelerate malignant progression and increase metastasis. The recent development of new drugs highly toxic to hypoxic cells may bring new strategies in anticancer treatments and move this condition from being a problem to a new tool in cancer control.
| Original language | English |
|---|---|
| Pages (from-to) | 340-342 |
| Number of pages | 3 |
| Journal | European Journal of Surgical Oncology |
| Volume | 27 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2001 |
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Keywords
- Hyperthermia
- Hypoxia
- Intra-arterial chemotherapy
- Tirapazamine
ASJC Scopus subject areas
- Oncology
- Surgery
Cite this
Hyperthermia and hypoxia : New developments in anticancer chemotherapy. / Zaffaroni, N.; Fiorentini, G.; De Giorgi, U.
In: European Journal of Surgical Oncology, Vol. 27, No. 4, 2001, p. 340-342.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hyperthermia and hypoxia
T2 - New developments in anticancer chemotherapy
AU - Zaffaroni, N.
AU - Fiorentini, G.
AU - De Giorgi, U.
PY - 2001
Y1 - 2001
N2 - It has been demonstrated in vitro and in vivo that hyperthermia can enhance the cytotoxicity of some chemotherapeutic agents. The in vivo studies have demonstrated that the thermal advantage is maximized at mild temperatures such as at 40.5-43°C. Thermo-chemotherapy is widely applied in limb perfusion and intraperitoneal chemotherapy. Hypoxia in solid tumours leads to resistance to most anticancer drugs and appears to accelerate malignant progression and increase metastasis. The recent development of new drugs highly toxic to hypoxic cells may bring new strategies in anticancer treatments and move this condition from being a problem to a new tool in cancer control.
AB - It has been demonstrated in vitro and in vivo that hyperthermia can enhance the cytotoxicity of some chemotherapeutic agents. The in vivo studies have demonstrated that the thermal advantage is maximized at mild temperatures such as at 40.5-43°C. Thermo-chemotherapy is widely applied in limb perfusion and intraperitoneal chemotherapy. Hypoxia in solid tumours leads to resistance to most anticancer drugs and appears to accelerate malignant progression and increase metastasis. The recent development of new drugs highly toxic to hypoxic cells may bring new strategies in anticancer treatments and move this condition from being a problem to a new tool in cancer control.
KW - Hyperthermia
KW - Hypoxia
KW - Intra-arterial chemotherapy
KW - Tirapazamine
UR - http://www.scopus.com/inward/record.url?scp=0034932740&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034932740&partnerID=8YFLogxK
U2 - 10.1053/ejso.2000.1040
DO - 10.1053/ejso.2000.1040
M3 - Article
VL - 27
SP - 340
EP - 342
JO - European Journal of Surgical Oncology
JF - European Journal of Surgical Oncology
SN - 0748-7983
IS - 4
ER -