Hyperthermia and hypoxia

New developments in anticancer chemotherapy

N. Zaffaroni, G. Fiorentini, U. De Giorgi

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

It has been demonstrated in vitro and in vivo that hyperthermia can enhance the cytotoxicity of some chemotherapeutic agents. The in vivo studies have demonstrated that the thermal advantage is maximized at mild temperatures such as at 40.5-43°C. Thermo-chemotherapy is widely applied in limb perfusion and intraperitoneal chemotherapy. Hypoxia in solid tumours leads to resistance to most anticancer drugs and appears to accelerate malignant progression and increase metastasis. The recent development of new drugs highly toxic to hypoxic cells may bring new strategies in anticancer treatments and move this condition from being a problem to a new tool in cancer control.

Original languageEnglish
Pages (from-to)340-342
Number of pages3
JournalEuropean Journal of Surgical Oncology
Volume27
Issue number4
DOIs
Publication statusPublished - 2001

Fingerprint

Fever
Drug Therapy
Poisons
Pharmaceutical Preparations
Neoplasms
Extremities
Perfusion
Hot Temperature
Neoplasm Metastasis
Temperature
Hypoxia
Therapeutics
In Vitro Techniques

Keywords

  • Hyperthermia
  • Hypoxia
  • Intra-arterial chemotherapy
  • Tirapazamine

ASJC Scopus subject areas

  • Oncology
  • Surgery

Cite this

Hyperthermia and hypoxia : New developments in anticancer chemotherapy. / Zaffaroni, N.; Fiorentini, G.; De Giorgi, U.

In: European Journal of Surgical Oncology, Vol. 27, No. 4, 2001, p. 340-342.

Research output: Contribution to journalArticle

@article{30a5cc7cbfad4f3ab579f746fa54a82c,
title = "Hyperthermia and hypoxia: New developments in anticancer chemotherapy",
abstract = "It has been demonstrated in vitro and in vivo that hyperthermia can enhance the cytotoxicity of some chemotherapeutic agents. The in vivo studies have demonstrated that the thermal advantage is maximized at mild temperatures such as at 40.5-43°C. Thermo-chemotherapy is widely applied in limb perfusion and intraperitoneal chemotherapy. Hypoxia in solid tumours leads to resistance to most anticancer drugs and appears to accelerate malignant progression and increase metastasis. The recent development of new drugs highly toxic to hypoxic cells may bring new strategies in anticancer treatments and move this condition from being a problem to a new tool in cancer control.",
keywords = "Hyperthermia, Hypoxia, Intra-arterial chemotherapy, Tirapazamine",
author = "N. Zaffaroni and G. Fiorentini and {De Giorgi}, U.",
year = "2001",
doi = "10.1053/ejso.2000.1040",
language = "English",
volume = "27",
pages = "340--342",
journal = "European Journal of Surgical Oncology",
issn = "0748-7983",
publisher = "W.B. Saunders Ltd",
number = "4",

}

TY - JOUR

T1 - Hyperthermia and hypoxia

T2 - New developments in anticancer chemotherapy

AU - Zaffaroni, N.

AU - Fiorentini, G.

AU - De Giorgi, U.

PY - 2001

Y1 - 2001

N2 - It has been demonstrated in vitro and in vivo that hyperthermia can enhance the cytotoxicity of some chemotherapeutic agents. The in vivo studies have demonstrated that the thermal advantage is maximized at mild temperatures such as at 40.5-43°C. Thermo-chemotherapy is widely applied in limb perfusion and intraperitoneal chemotherapy. Hypoxia in solid tumours leads to resistance to most anticancer drugs and appears to accelerate malignant progression and increase metastasis. The recent development of new drugs highly toxic to hypoxic cells may bring new strategies in anticancer treatments and move this condition from being a problem to a new tool in cancer control.

AB - It has been demonstrated in vitro and in vivo that hyperthermia can enhance the cytotoxicity of some chemotherapeutic agents. The in vivo studies have demonstrated that the thermal advantage is maximized at mild temperatures such as at 40.5-43°C. Thermo-chemotherapy is widely applied in limb perfusion and intraperitoneal chemotherapy. Hypoxia in solid tumours leads to resistance to most anticancer drugs and appears to accelerate malignant progression and increase metastasis. The recent development of new drugs highly toxic to hypoxic cells may bring new strategies in anticancer treatments and move this condition from being a problem to a new tool in cancer control.

KW - Hyperthermia

KW - Hypoxia

KW - Intra-arterial chemotherapy

KW - Tirapazamine

UR - http://www.scopus.com/inward/record.url?scp=0034932740&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034932740&partnerID=8YFLogxK

U2 - 10.1053/ejso.2000.1040

DO - 10.1053/ejso.2000.1040

M3 - Article

VL - 27

SP - 340

EP - 342

JO - European Journal of Surgical Oncology

JF - European Journal of Surgical Oncology

SN - 0748-7983

IS - 4

ER -