Hyperthermia and hypoxia: New developments in anticancer chemotherapy

N. Zaffaroni; G. Fiorentini; U. De Giorgi

doi:10.1053/ejso.2000.1040

Hyperthermia and hypoxia: New developments in anticancer chemotherapy

N. Zaffaroni, G. Fiorentini, U. De Giorgi

Research output: Contribution to journal › Article › peer-review

Abstract

It has been demonstrated in vitro and in vivo that hyperthermia can enhance the cytotoxicity of some chemotherapeutic agents. The in vivo studies have demonstrated that the thermal advantage is maximized at mild temperatures such as at 40.5-43°C. Thermo-chemotherapy is widely applied in limb perfusion and intraperitoneal chemotherapy. Hypoxia in solid tumours leads to resistance to most anticancer drugs and appears to accelerate malignant progression and increase metastasis. The recent development of new drugs highly toxic to hypoxic cells may bring new strategies in anticancer treatments and move this condition from being a problem to a new tool in cancer control.

Original language	English
Pages (from-to)	340-342
Number of pages	3
Journal	European Journal of Surgical Oncology
Volume	27
Issue number	4
DOIs	https://doi.org/10.1053/ejso.2000.1040
Publication status	Published - 2001

Keywords

Hyperthermia
Hypoxia
Intra-arterial chemotherapy
Tirapazamine

ASJC Scopus subject areas

Oncology
Surgery

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10.1053/ejso.2000.1040

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AU - De Giorgi, U.

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AB - It has been demonstrated in vitro and in vivo that hyperthermia can enhance the cytotoxicity of some chemotherapeutic agents. The in vivo studies have demonstrated that the thermal advantage is maximized at mild temperatures such as at 40.5-43°C. Thermo-chemotherapy is widely applied in limb perfusion and intraperitoneal chemotherapy. Hypoxia in solid tumours leads to resistance to most anticancer drugs and appears to accelerate malignant progression and increase metastasis. The recent development of new drugs highly toxic to hypoxic cells may bring new strategies in anticancer treatments and move this condition from being a problem to a new tool in cancer control.

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KW - Intra-arterial chemotherapy

KW - Tirapazamine

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Hyperthermia and hypoxia: New developments in anticancer chemotherapy

Abstract

Keywords

ASJC Scopus subject areas

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