Abstract
Isolated hepatic perfusion (IHP) is a recently reconsidered locoregional approach for unresectable primary or metastatic cancer and encouraging results have been achieved from its clinical application. Ten patients underwent hyperthermic IHP with melphalan. There was no intraoperative mortality. In the postoperative period two patients died due to multi-organ failure. Four patients had significant but transient hepatic toxicity. In 8 assessable patients, the overall response rate was 63%. We observed objective tumor regression in a significant percentage of patients refractory to standard treatments. Locoregional toxicity was significant, which underscores the need for a more accurate preoperative evaluation of hepatic function.
| Original language | English |
|---|---|
| Pages (from-to) | 37-39 |
| Number of pages | 3 |
| Journal | Journal of Chemotherapy |
| Volume | 16 |
| Issue number | SUPPL. 5 |
| Publication status | Published - Nov 2004 |
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Keywords
- Isolated hepatic perfusion
- Isolated liver perfusion
- Liver cancer
ASJC Scopus subject areas
- Pharmacology (medical)
- Microbiology (medical)
Cite this
Hyperthermic isolated liver perfusion for unresectable liver cancers : Pilot study. / Lise, Mario; Pilati, P.; Da Pian, P.; Mocellin, S.; Ori, C.; Casara, D.; Rossi, C. R.; Darisi, T.; Corazzina, S.; Nitti, D.
In: Journal of Chemotherapy, Vol. 16, No. SUPPL. 5, 11.2004, p. 37-39.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hyperthermic isolated liver perfusion for unresectable liver cancers
T2 - Pilot study
AU - Lise, Mario
AU - Pilati, P.
AU - Da Pian, P.
AU - Mocellin, S.
AU - Ori, C.
AU - Casara, D.
AU - Rossi, C. R.
AU - Darisi, T.
AU - Corazzina, S.
AU - Nitti, D.
PY - 2004/11
Y1 - 2004/11
N2 - Isolated hepatic perfusion (IHP) is a recently reconsidered locoregional approach for unresectable primary or metastatic cancer and encouraging results have been achieved from its clinical application. Ten patients underwent hyperthermic IHP with melphalan. There was no intraoperative mortality. In the postoperative period two patients died due to multi-organ failure. Four patients had significant but transient hepatic toxicity. In 8 assessable patients, the overall response rate was 63%. We observed objective tumor regression in a significant percentage of patients refractory to standard treatments. Locoregional toxicity was significant, which underscores the need for a more accurate preoperative evaluation of hepatic function.
AB - Isolated hepatic perfusion (IHP) is a recently reconsidered locoregional approach for unresectable primary or metastatic cancer and encouraging results have been achieved from its clinical application. Ten patients underwent hyperthermic IHP with melphalan. There was no intraoperative mortality. In the postoperative period two patients died due to multi-organ failure. Four patients had significant but transient hepatic toxicity. In 8 assessable patients, the overall response rate was 63%. We observed objective tumor regression in a significant percentage of patients refractory to standard treatments. Locoregional toxicity was significant, which underscores the need for a more accurate preoperative evaluation of hepatic function.
KW - Isolated hepatic perfusion
KW - Isolated liver perfusion
KW - Liver cancer
UR - http://www.scopus.com/inward/record.url?scp=19944428511&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=19944428511&partnerID=8YFLogxK
M3 - Article
C2 - 15675475
AN - SCOPUS:19944428511
VL - 16
SP - 37
EP - 39
JO - Journal of Chemotherapy
JF - Journal of Chemotherapy
SN - 1120-009X
IS - SUPPL. 5
ER -