Hyperthermic isolated liver perfusion for unresectable liver cancers: Pilot study

Mario Lise, P. Pilati, P. Da Pian, S. Mocellin, C. Ori, D. Casara, C. R. Rossi, T. Darisi, S. Corazzina, D. Nitti

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Isolated hepatic perfusion (IHP) is a recently reconsidered locoregional approach for unresectable primary or metastatic cancer and encouraging results have been achieved from its clinical application. Ten patients underwent hyperthermic IHP with melphalan. There was no intraoperative mortality. In the postoperative period two patients died due to multi-organ failure. Four patients had significant but transient hepatic toxicity. In 8 assessable patients, the overall response rate was 63%. We observed objective tumor regression in a significant percentage of patients refractory to standard treatments. Locoregional toxicity was significant, which underscores the need for a more accurate preoperative evaluation of hepatic function.

Original languageEnglish
Pages (from-to)37-39
Number of pages3
JournalJournal of Chemotherapy
Volume16
Issue numberSUPPL. 5
Publication statusPublished - Nov 2004

Fingerprint

Liver Neoplasms
Perfusion
Liver
Melphalan
Postoperative Period
Neoplasms
Mortality
Therapeutics

Keywords

  • Isolated hepatic perfusion
  • Isolated liver perfusion
  • Liver cancer

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Microbiology (medical)

Cite this

Lise, M., Pilati, P., Da Pian, P., Mocellin, S., Ori, C., Casara, D., ... Nitti, D. (2004). Hyperthermic isolated liver perfusion for unresectable liver cancers: Pilot study. Journal of Chemotherapy, 16(SUPPL. 5), 37-39.

Hyperthermic isolated liver perfusion for unresectable liver cancers : Pilot study. / Lise, Mario; Pilati, P.; Da Pian, P.; Mocellin, S.; Ori, C.; Casara, D.; Rossi, C. R.; Darisi, T.; Corazzina, S.; Nitti, D.

In: Journal of Chemotherapy, Vol. 16, No. SUPPL. 5, 11.2004, p. 37-39.

Research output: Contribution to journalArticle

Lise, M, Pilati, P, Da Pian, P, Mocellin, S, Ori, C, Casara, D, Rossi, CR, Darisi, T, Corazzina, S & Nitti, D 2004, 'Hyperthermic isolated liver perfusion for unresectable liver cancers: Pilot study', Journal of Chemotherapy, vol. 16, no. SUPPL. 5, pp. 37-39.
Lise M, Pilati P, Da Pian P, Mocellin S, Ori C, Casara D et al. Hyperthermic isolated liver perfusion for unresectable liver cancers: Pilot study. Journal of Chemotherapy. 2004 Nov;16(SUPPL. 5):37-39.
Lise, Mario ; Pilati, P. ; Da Pian, P. ; Mocellin, S. ; Ori, C. ; Casara, D. ; Rossi, C. R. ; Darisi, T. ; Corazzina, S. ; Nitti, D. / Hyperthermic isolated liver perfusion for unresectable liver cancers : Pilot study. In: Journal of Chemotherapy. 2004 ; Vol. 16, No. SUPPL. 5. pp. 37-39.
@article{6747a2b6b553487e8c3937e178806d75,
title = "Hyperthermic isolated liver perfusion for unresectable liver cancers: Pilot study",
abstract = "Isolated hepatic perfusion (IHP) is a recently reconsidered locoregional approach for unresectable primary or metastatic cancer and encouraging results have been achieved from its clinical application. Ten patients underwent hyperthermic IHP with melphalan. There was no intraoperative mortality. In the postoperative period two patients died due to multi-organ failure. Four patients had significant but transient hepatic toxicity. In 8 assessable patients, the overall response rate was 63{\%}. We observed objective tumor regression in a significant percentage of patients refractory to standard treatments. Locoregional toxicity was significant, which underscores the need for a more accurate preoperative evaluation of hepatic function.",
keywords = "Isolated hepatic perfusion, Isolated liver perfusion, Liver cancer",
author = "Mario Lise and P. Pilati and {Da Pian}, P. and S. Mocellin and C. Ori and D. Casara and Rossi, {C. R.} and T. Darisi and S. Corazzina and D. Nitti",
year = "2004",
month = "11",
language = "English",
volume = "16",
pages = "37--39",
journal = "Journal of Chemotherapy",
issn = "1120-009X",
publisher = "Maney Publishing",
number = "SUPPL. 5",

}

TY - JOUR

T1 - Hyperthermic isolated liver perfusion for unresectable liver cancers

T2 - Pilot study

AU - Lise, Mario

AU - Pilati, P.

AU - Da Pian, P.

AU - Mocellin, S.

AU - Ori, C.

AU - Casara, D.

AU - Rossi, C. R.

AU - Darisi, T.

AU - Corazzina, S.

AU - Nitti, D.

PY - 2004/11

Y1 - 2004/11

N2 - Isolated hepatic perfusion (IHP) is a recently reconsidered locoregional approach for unresectable primary or metastatic cancer and encouraging results have been achieved from its clinical application. Ten patients underwent hyperthermic IHP with melphalan. There was no intraoperative mortality. In the postoperative period two patients died due to multi-organ failure. Four patients had significant but transient hepatic toxicity. In 8 assessable patients, the overall response rate was 63%. We observed objective tumor regression in a significant percentage of patients refractory to standard treatments. Locoregional toxicity was significant, which underscores the need for a more accurate preoperative evaluation of hepatic function.

AB - Isolated hepatic perfusion (IHP) is a recently reconsidered locoregional approach for unresectable primary or metastatic cancer and encouraging results have been achieved from its clinical application. Ten patients underwent hyperthermic IHP with melphalan. There was no intraoperative mortality. In the postoperative period two patients died due to multi-organ failure. Four patients had significant but transient hepatic toxicity. In 8 assessable patients, the overall response rate was 63%. We observed objective tumor regression in a significant percentage of patients refractory to standard treatments. Locoregional toxicity was significant, which underscores the need for a more accurate preoperative evaluation of hepatic function.

KW - Isolated hepatic perfusion

KW - Isolated liver perfusion

KW - Liver cancer

UR - http://www.scopus.com/inward/record.url?scp=19944428511&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=19944428511&partnerID=8YFLogxK

M3 - Article

C2 - 15675475

AN - SCOPUS:19944428511

VL - 16

SP - 37

EP - 39

JO - Journal of Chemotherapy

JF - Journal of Chemotherapy

SN - 1120-009X

IS - SUPPL. 5

ER -